ReferenceID 1303
Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
Mar Drugs
The tricyclic quinazoline alkaloid deoxyvasicinone ( DOV , 1 ) was isolated from a marine-derived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the me
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 1303
- Evidence Id
- 17893
- Core Evidence Id
- 17893
- Source Reference Id
- 3496
- Herb2 Reference Id
- HBREF004293
- Subject Paper Key
- HBIN023402_35200684
- Pubmed Id
- 35200684
- Doi
- 10.3390/md20020155
- Paper Title
- Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
- Paper Abstract
- The tricyclic quinazoline alkaloid deoxyvasicinone ( DOV , 1 ) was isolated from a marine-derived Streptomyces sp. CNQ-617, and its anti-melanogenic effects were investigated. Deoxyvasicinone was shown to decrease the melanin content of B16F10 and MNT-1 cells that have been stimulated by α-melanocyte-stimulating hormone (α-MSH). In addition, microscopic images of the cells showed that deoxyvasicinone attenuated melanocyte activation. Although, deoxyvasicinone did not directly inhibit tyrosinase (TYR) enzymatic activity, real-time PCR showed that it inhibited the mRNA expression of TYR, tyrosinase-related protein 1 (TRP-1), and tyrosinase-related protein 2 (TRP-2). In the artificial 3D pigmented skin model Melanoderm TM , deoxyvasicinone brightened the skin significantly, as confirmed by histological examination. In conclusion, this study demonstrated that the marine microbial natural product deoxyvascinone has an anti-melanogenic effect through downregulation of melanogenic enzymes.
- Journal
- Mar Drugs
- Publish Year
- 2022
- Experiment Subject
- b16f10 and mnt-1 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Paper Title Cn
- Paper Title En
- Deoxyvasicinone with Anti-Melanogenic Activity from Marine-Derived Streptomyces sp. CNQ-617
- Bilingual Status
- semi_complete