ReferenceID 1226
Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro
Bioengineered
Ischemia/reperfusion injury (I/R) is the main causes of acute kidney injury (AKI), which is a global health concern. Evidence suggests that asiaticoside plays vital roles on anti-inflammatory and, anti-kidney fibrosis ef
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Record Fields
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- Reference Id
- 1226
- Evidence Id
- 17816
- Core Evidence Id
- 17816
- Source Reference Id
- 2444
- Herb2 Reference Id
- HBREF003241
- Subject Paper Key
- HBIN017061_35435108
- Pubmed Id
- 35435108
- Doi
- 10.1080/21655979.2022.2061302
- Paper Title
- Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro
- Paper Abstract
- Ischemia/reperfusion injury (I/R) is the main causes of acute kidney injury (AKI), which is a global health concern. Evidence suggests that asiaticoside plays vital roles on anti-inflammatory and, anti-kidney fibrosis effects, and promotes tissue repair. However, the effects of asiaticoside on AKI caused by ischemia-reperfusion have not been well defined. Herein, we explored the protective effect of asiaticoside on renal ischemia-reperfusion injury (IRI) using in vivo and in vitro studies, and elucidated the potential mechanism of asiaticoside-mediated repair. Results showed that asiaticoside attenuated the levels of blood urea nitrogen (BUN) and serum creatinine (Scr) in the IRI model. Meanwhile, asiaticoside reduced the secretion of IL-6, IL-1β and TNF-α, but increased IL-10 secretion in a dose-dependent manner. Treating Raw264.7 cells with lipopolysaccharide (LPS) induced an inflammatory response, but the LPS-induced effects were attenuated after administering asiaticoside. Furthermore, asiaticoside significantly inhibited the expression of inducible Nitric Oxide Synthase (iNOS) and promoted the expression of Arginase1 induced by LPS, which are the polarization marker proteins. In conclusion, this study shows that asiaticoside possesses protective action in AKI after ischemia-reperfusion, due to the inhibition of inflammatory mediators and promoting transformation of macrophages from M1 type to M2 type.
- Journal
- Bioengineered
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Renal Ischemia-reperfusion Injury; Ischemia/reperfusion Injury; Acute Kidney Injury
- Paper Title Cn
- Paper Title En
- Protective effects of asiaticoside on renal ischemia reperfusion injury in vivo and in vitro
- Bilingual Status
- semi_complete