ReferenceID 1210
Ameliorative Effects of Arctigenin on Pulmonary Fibrosis Induced by Bleomycin via the Antioxidant Activity
Oxid Med Cell Longev
In this study, we evaluated the in vivo effect of arctigenin (ATG) on bleomycin-induced pulmonary fibrosis in mice and assessed the role of antioxidant activity. Hematoxylin and eosin (H&E) staining, the results of Masso
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Record Fields
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- Reference Id
- 1210
- Evidence Id
- 17800
- Core Evidence Id
- 17800
- Source Reference Id
- 2408
- Herb2 Reference Id
- HBREF003205
- Subject Paper Key
- HBIN016609_35847593
- Pubmed Id
- 35847593
- Doi
- 10.1155/2022/3541731
- Paper Title
- Ameliorative Effects of Arctigenin on Pulmonary Fibrosis Induced by Bleomycin via the Antioxidant Activity
- Paper Abstract
- In this study, we evaluated the in vivo effect of arctigenin (ATG) on bleomycin-induced pulmonary fibrosis in mice and assessed the role of antioxidant activity. Hematoxylin and eosin (H&E) staining, the results of Masson's trichrome, and Sirius red staining showed that bleomycin induced obvious pathological changes and collagen deposition in the lung tissue of mice, which were effectively inhibited by ATG. Specifically, based on immunohistochemistry and western blot results, ATG inhibited the expression of fibrosis markers, such as collagen, fibronectin, and α -SMA. Moreover, ATG regulated reactive oxygen species (ROS), superoxide dismutase (SOD), malondialdehyde (MDA), and glutathione (GSH) in the lung tissue of pulmonary fibrosis mice and reduced the pressure of oxidative stress. ATG also regulated the TGF- β -induced expression of p-Akt, confirming that ATG can inhibit fibrosis through antioxidant activity modulation.
- Journal
- Oxid Med Cell Longev
- Publish Year
- 2022
- Experiment Subject
- mouse
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Pulmonary Fibrosis; Fibrosis
- Paper Title Cn
- Paper Title En
- Ameliorative Effects of Arctigenin on Pulmonary Fibrosis Induced by Bleomycin via the Antioxidant Activity
- Bilingual Status
- semi_complete