ReferenceID 1160
Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity
Life Sci
AIM: This study aimed to reveal the effects of icaritin (ICT) on lipotoxicity induced by palmitate (PA) in hepatic cells and steatosis in high-fat diet (HFD)-fed mice as well as exploring the potential mechanisms. MAIN M
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- Reference Id
- 1160
- Evidence Id
- 17750
- Core Evidence Id
- 17750
- Source Reference Id
- 2297
- Herb2 Reference Id
- HBREF003094
- Subject Paper Key
- HBIN016163_33417961
- Pubmed Id
- 33417961
- Doi
- 10.1016/j.lfs.2020.119000
- Paper Title
- Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity
- Paper Abstract
- AIM: This study aimed to reveal the effects of icaritin (ICT) on lipotoxicity induced by palmitate (PA) in hepatic cells and steatosis in high-fat diet (HFD)-fed mice as well as exploring the potential mechanisms. MAIN METHODS: Primary mouse hepatocytes and human hepatoma Huh7 cells were used to evaluate ICT effect in vitro. HFD-fed mice were used to evaluate the ICT effect in vivo. RESULTS: In vitro study indicated that ICT significantly rescued PA-induced steatosis, mainly through a combination of robust increased mitochondrial respiration, fatty acid oxidation and mildly decreased synthesis of fatty acid. An HFD-fed mouse model with 8 weeks HFD-fed showed metabolic disorders, while ICT application significantly reduced the weight, serum glucose levels, insulin resistance, hepatic steatosis level and adipose contents. In consistent with the observations in cell lines, ICT rescued the HFD-impaired functions and contents of key factors related to fatty acid beta-oxidation through elevated expression of peroxisome proliferator-activated receptor alpha (PPARalpha). Meanwhile, it also reversed the decreased phosphoryl levels of AKT and glucogen synthase kinase 3 (GSK3beta), leading to the improvement of insulin resistance. SIGNIFICANCE: ICT administration had a therapeutic effect on PA- or HFD-induced hepatic steatosis and metabolic disorders. It may provide a novel strategy to construct preventive and therapeutic means for hepatic steatosis.
- Journal
- Life Sci
- Publish Year
- 2021
- Experiment Subject
- mouse; human; cell lines; human hepatoma huh7 cells
- Experiment Type
- Cell Experiment
- Phenotype Related
- Hepatoma; Metabolic Disorders; Hepatic Steatosis; Steatosis
- Paper Title Cn
- Paper Title En
- Icaritin ameliorates hepatic steatosis via promoting fatty acid β-oxidation and insulin sensitivity
- Bilingual Status
- semi_complete