ReferenceID 1130
Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate
J Cell Physiol
An abnormal urine composition is a key reason for kidney stone formation, but little is known about the roles of small metabolites in the urine during kidney stone formation. Here, we found urine glycine in patients with
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 1130
- Evidence Id
- 17720
- Core Evidence Id
- 17720
- Source Reference Id
- 2241
- Herb2 Reference Id
- HBREF003038
- Subject Paper Key
- HBIN015853_33772775
- Pubmed Id
- 33772775
- Doi
- 10.1002/jcp.30370
- Paper Title
- Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate
- Paper Abstract
- An abnormal urine composition is a key reason for kidney stone formation, but little is known about the roles of small metabolites in the urine during kidney stone formation. Here, we found urine glycine in patients with kidney calcium oxalate (CaOx) stone was significantly lower than that in healthy people via 1 H NMR spectra detection, and investigated the role and underlying mechanism of glycine in the regulation of CaOx stone formation. Our results showed that glycine could significantly attenuate ethylene glycol-induced CaOx crystal depositions in rat kidney via decreasing urine oxalate and increasing urine citrate. Mechanism studies revealed that glycine could decrease urine oxalate through downregulating Slc26a6 expression, whereas increase urine citrate via inhibiting Nadc1 expression. Moreover, glycine decreased the protein expression of both Slc26a6 and Nadc1 via increasing the expression of miRNA-411-3p, which directly bound to the 3'-untranslated regions of Slc26a6 and Nadc1 messenger RNAs, in vitro and in vivo. Together, our results revealed a novel role of glycine in the regulation of kidney CaOx crystal formation and provided a potential target for the treatment of kidney CaOx stone.
- Journal
- J Cell Physiol
- Publish Year
- 2021
- Experiment Subject
- rat; patient; people
- Experiment Type
- Animal Experiment
- Phenotype Related
- Kidney Caox Stone
- Paper Title Cn
- Paper Title En
- Glycine suppresses kidney calcium oxalate crystal depositions via regulating urinary excretions of oxalate and citrate
- Bilingual Status
- semi_complete