ReferenceID 1118
The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
Int J Mol Sci
As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This
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- Reference Id
- 1118
- Evidence Id
- 17708
- Core Evidence Id
- 17708
- Source Reference Id
- 2213
- Herb2 Reference Id
- HBREF003010
- Subject Paper Key
- HBIN015313_34769051
- Pubmed Id
- 34769051
- Doi
- 10.3390/ijms222111620
- Paper Title
- The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
- Paper Abstract
- As a class of difurancoumarin compounds with similar structures, aflatoxins (AF) are commonly found in the environment, soil, and food crops. AF pose a serious threat to the health of humans, poultry, and livestock. This study aimed to investigate the neuroprotective effect and detailed mechanism of aloin on hepatic injury induced by subchronic AFB1 in rats. The result showed that aloin could significantly inhibit the decrease in food intake, body weight growth, immune organ index, and serum albumin content caused by long-term AFB1 exposure. Meanwhile, aloin reduced the level of serum liver function and improved renal swelling and pathological changes of liver tissue. Aloin could also inhibit liver lipid peroxidation and improve liver antioxidant capacity. Further investigation revealed that aloin inhibited the activity and expression of hepatic CYP1A2 and CYP3A4 and down-regulated IL-1beta expression in subchronic AFB1-induced liver injury rats. The above study demonstrated that aloin played an important role in blocking or delaying the development process of subchronic AFB1-induced hepatotoxicity. Therefore, aloin is considered to have a potential role as a protective agent against AFB1.
- Journal
- Int J Mol Sci
- Publish Year
- 2021
- Experiment Subject
- rat; human
- Experiment Type
- Animal Experiment
- Phenotype Related
- Renal Swelling
- Paper Title Cn
- Paper Title En
- The Intervention and Mechanism of Action for Aloin against Subchronic Aflatoxin B1 Induced Hepatic Injury in Rats
- Bilingual Status
- semi_complete