ReferenceID 1110
Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway
Food Funct
Steroid-induced avascular necrosis of the femoral head (SANFH) is a major complication of long-term or excessive clinical use of glucocorticoids. Allicin is a classical ingredient extracted from garlic and has many funct
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Record Fields
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- Reference Id
- 1110
- Evidence Id
- 17700
- Core Evidence Id
- 17700
- Source Reference Id
- 2197
- Herb2 Reference Id
- HBREF002994
- Subject Paper Key
- HBIN015200_32808945
- Pubmed Id
- 32808945
- Doi
- 10.1039/d0fo00837k
- Paper Title
- Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway
- Paper Abstract
- Steroid-induced avascular necrosis of the femoral head (SANFH) is a major complication of long-term or excessive clinical use of glucocorticoids. Allicin is a classical ingredient extracted from garlic and has many functions such as anti-apoptosis and antibacterial effects. The purpose of this study was to investigate the effect and the mechanism of allicin on apoptosis of osteoblasts induced by dexamethasone (Dex) and SANFH in rats. In vitro, we performed CCK-8, western blotting, TUNEL and other experiments, and the results of these experiments showed that allicin could inhibit the Dex-induced abnormal expression of C-caspase3, C-caspase9, Bax, cytochrome C and Bcl-2 by activating the PI3K/AKT pathway. In vivo, the results of micro-CT, hematoxylin-eosin staining and immunohistochemical analysis suggested that allicin could effectively inhibit the progress of SANFH in rats. In summary, our experiments indicate that allicin is a potential drug for the treatment of SANFH.
- Journal
- Food Funct
- Publish Year
- 2020
- Experiment Subject
- rat; garlic
- Experiment Type
- Cell Experiment
- Phenotype Related
- Steroid-induced Avascular Necrosis Of The Femoral Head
- Paper Title Cn
- Paper Title En
- Allicin inhibits osteoblast apoptosis and steroid-induced necrosis of femoral head progression by activating the PI3K/AKT pathway
- Bilingual Status
- semi_complete