ReferenceID 1108
Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation
Int J Biol Sci
The current performance of nature compounds in antitumor field is gradually attracted more and more attention, we discovered a nature active ingredient alizarin possess potent natural reductive NF-κB activity to against
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- Reference Id
- 1108
- Evidence Id
- 17698
- Core Evidence Id
- 17698
- Source Reference Id
- 2195
- Herb2 Reference Id
- HBREF002992
- Subject Paper Key
- HBIN015161_35541911
- Pubmed Id
- 35541911
- Doi
- 10.7150/ijbs.70567
- Paper Title
- Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation
- Paper Abstract
- The current performance of nature compounds in antitumor field is gradually attracted more and more attention, we discovered a nature active ingredient alizarin possess potent natural reductive NF-κB activity to against pancreatic cancer. However, the preclinical pharmacology and therapeutic effect, and the underlying mechanisms of alizarin in inhibiting pancreatic cancer are still unclear. After high-throughput screening, this is the first report that alizarin can induce a potent inhibitory effect against pancreatic cancer cells. Alizarin induced cell cycle arrest and promoted cell apoptosis by inhibiting TNF-α-stimulated NF-κB activity and nuclear translocation, and inactivated its related TNF-α-TAK1-NF-κB signaling cascade followed by downregulation of NF-κB target genes involved in cell apoptosis (Bcl-2, Bcl-xL, XIAP) and in the cell cycle and growth (cyclin D, c-myc). Due to the abrogation of NF-κB activity, combination of alizarin and gemcitabine exerted a better inhibitory effect on pancreatic cancer. In summary, natural component alizarin, inhibited cell proliferation and induced apoptosis in vitro and in vivo through targeting of the NF-κB signaling cascade with minimal toxicity, which combine with gemcitabine, can significantly enhance the antitumor capability, playing a synergistic effect. Therefore, alizarin may play a role in reversing gemcitabine resistance caused by overactivated NF-κB in clinical application in the future.
- Journal
- Int J Biol Sci
- Publish Year
- 2022
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Pancreatic Cancer
- Paper Title Cn
- Paper Title En
- Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation
- Bilingual Status
- semi_complete