ReferenceID 1097
The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination
Pharmacol Res
Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microgl
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Record Fields
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- Reference Id
- 1097
- Evidence Id
- 17687
- Core Evidence Id
- 17687
- Source Reference Id
- 2177
- Herb2 Reference Id
- HBREF002974
- Subject Paper Key
- HBIN014830_32534098
- Pubmed Id
- 32534098
- Doi
- 10.1016/j.phrs.2020.104997
- Paper Title
- The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination
- Paper Abstract
- Myelin loss is the hallmark of the demyelinating disease multiple sclerosis (MS) and plays a significant role in multiple neurodegenerative diseases. A common factor in all neuropathologies is the central role of microglia, the intrinsic immune cells of the central nervous system (CNS). Microglia are activated in pathology and can have both pro- and anti-inflammatory functions. Here, we examined the effects of the flavonoid agathisflavone on microglia and remyelination in the cerebellar slice model following lysolecithin induced demyelination. Notably, agathisflavone enhances remyelination and alters microglial activation state, as determined by their morphology and cytokine profile. Furthermore, these effects of agathisflavone on remyelination and microglial activation were inhibited by blockade of estrogen receptor alpha. Thus, our results identify agathisflavone as a novel compound that may act via ER to regulate microglial activation and enhance remyelination and repair.
- Journal
- Pharmacol Res
- Publish Year
- 2020
- Experiment Subject
- Experiment Type
- Cell Experiment
- Phenotype Related
- Demyelination; Demyelinating Disease Multiple Sclerosis; Neurodegenerative Diseases
- Paper Title Cn
- Paper Title En
- The flavonoid agathisflavone modulates the microglial neuroinflammatory response and enhances remyelination
- Bilingual Status
- semi_complete