ReferenceID 1076
Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway
J Cell Mol Med
Ultraviolet A (UVA) radiation is a major contributor to the pathogenesis of skin photoaging, and the aim of this study was to investigate the effect of Acacetin on skin photoaging in UVA-irradiated mice and human dermal
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- Reference Id
- 1076
- Evidence Id
- 17666
- Core Evidence Id
- 17666
- Source Reference Id
- 2142
- Herb2 Reference Id
- HBREF002939
- Subject Paper Key
- HBIN014294_35765710
- Pubmed Id
- 35765710
- Doi
- 10.1111/jcmm.17415
- Paper Title
- Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway
- Paper Abstract
- Ultraviolet A (UVA) radiation is a major contributor to the pathogenesis of skin photoaging, and the aim of this study was to investigate the effect of Acacetin on skin photoaging in UVA-irradiated mice and human dermal fibroblasts (HDF). Healthy dorsal depilated rats were irradiated with UVA 30 J/cm 2 daily, every other day, for 1 month. Acacetin (40, 80 mg kg/day) was coated to the bare skin of the rats' backs 1 h before UVA irradiation. HDF were treated different concentrations of Acacetin (5, 10, 20 μg/ml) and then irradiated with UVA (20 J/cm 2 ). Acacetin was found to be effective in ameliorating UVA-induced oxidative stress and cell death. Acacetin also prevented the UVA-induced decrease of SIRT3, reduced the activation of mitogen-activated protein kinases (MAPKs, p-38 and p-JNK) and blocked the down-regulated activation of oxidative stress in matrix metalloproteinases (MMPs). In addition, Acacetin increased the expressions of collagen-promoting proteins (TGF-β and Smad3). Finally, the SIRT3 inhibitor 3-TYP blocked all protective effects of Acacetin, indicating that the protective effect of Acacetin against UVA photoaging is SIRT3-dependent. Acacetin effectively mitigated photoaging by targeting the promotion of SIRT3, inhibiting the UVA-induced increases in MMPs and pro-inflammatory factors, and promoting TGF-β and Smad3.
- Journal
- J Cell Mol Med
- Publish Year
- 2022
- Experiment Subject
- mouse; rat; human
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Skin Photoaging
- Paper Title Cn
- Paper Title En
- Acacetin resists UVA photoaging by mediating the SIRT3/ROS/MAPKs pathway
- Bilingual Status
- semi_complete