ReferenceID 1063
Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model
Am J Physiol Lung Cell Mol Physiol
Asthma, a common disorder associated with airway inflammation and hyperresponsiveness, remains a significant clinical burden in need of novel therapeutic strategies. Patients are increasingly seeking complementary and al
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- Reference Id
- 1063
- Evidence Id
- 17653
- Core Evidence Id
- 17653
- Source Reference Id
- 2109
- Herb2 Reference Id
- HBREF002906
- Subject Paper Key
- HBIN012818_31800263
- Pubmed Id
- 31800263
- Doi
- 10.1152/ajplung.00249.2019
- Paper Title
- Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model
- Paper Abstract
- Asthma, a common disorder associated with airway inflammation and hyperresponsiveness, remains a significant clinical burden in need of novel therapeutic strategies. Patients are increasingly seeking complementary and alternative medicine approaches to control their symptoms, including the use of natural products. Ginger, a natural product that we previously demonstrated acutely relaxes airway smooth muscle (ASM), has long been reported to possess anti-inflammatory properties, although a precise mechanistic understanding is lacking. In these studies, we demonstrate that chronic administration of whole ginger extract or 6-shogaol, a bioactive component of ginger, mitigates in vivo house dust mite antigen-mediated lung inflammation in mice. We further show that this decrease in inflammation is associated with reduced in vivo airway responsiveness. Utilizing in vitro studies, we demonstrate that 6-shogaol augments cAMP concentrations in CD4 cells, consistent with phosphodiesterase inhibition, and limits the induction of nuclear factor-kappaB signaling and the production of proinflammatory cytokines in activated CD4 cells. Sustained elevations in cAMP concentration are well known to inhibit effector T cell function. Interestingly, regulatory T cells (Tregs) utilize cAMP as a mediator of their immunosuppressive effects, and we demonstrate here that 6-shogaol augments the Treg polarization of naive CD4 cells in vitro. Taken together with previous reports, these studies suggest that ginger and 6-shogaol have the potential to combat asthma via two mechanisms: acute ASM relaxation and chronic inhibition of inflammation.
- Journal
- Am J Physiol Lung Cell Mol Physiol
- Publish Year
- 2020
- Experiment Subject
- mouse; patient; ginger
- Experiment Type
- Animal & Cell Experiment
- Phenotype Related
- Asthma; Airway Inflammation
- Paper Title Cn
- Paper Title En
- Ginger and its bioactive component 6-shogaol mitigate lung inflammation in a murine asthma model
- Bilingual Status
- semi_complete