ReferenceID 1043
Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells in vitro and Its Cardioprotective Effects in vivo
Front Cell Dev Biol
Cardiac hypertrophy and fibrosis are major pathophysiologic disorders that lead to serious cardiovascular diseases (CVDs), such as heart failure and arrhythmia. It is well known that transforming growth factor beta (TGFb
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Record Fields
Scalar fields from the final reference record.
- Reference Id
- 1043
- Evidence Id
- 17633
- Core Evidence Id
- 17633
- Source Reference Id
- 2071
- Herb2 Reference Id
- HBREF002868
- Subject Paper Key
- HBIN008965_33117805
- Pubmed Id
- 33117805
- Doi
- 10.3389/fcell.2020.578197
- Paper Title
- Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells in vitro and Its Cardioprotective Effects in vivo
- Paper Abstract
- Cardiac hypertrophy and fibrosis are major pathophysiologic disorders that lead to serious cardiovascular diseases (CVDs), such as heart failure and arrhythmia. It is well known that transforming growth factor beta (TGFbeta) signaling pathways play a major role in the proliferation of cardiac hypertrophy and fibrosis, which is mainly stimulated by angiotensin II (AgII). This study aimed to investigate the cardioprotective potential of isorhamnetin (ISO) in human amniotic epithelial stem cells (hAESCs) through global gene expression analysis and to confirm its beneficial effects on cardiac hypertrophy and fibrosis in the AgII-induced in vivo model. In vitro, biological processes including TGFbeta, collagen-related functions, and inflammatory processes were significantly suppressed in ISO pretreated hAESCs. In vivo, continuous AgII infusion using an osmotic pump induced significant pathological fibrosis and myocardial hypertrophy, which were remarkably suppressed by ISO pretreatment. ISO was found to reverse the enhanced TGFbeta and Collagen type I alpha 1 mRNA expression induced by AgII exposure, which causes cardiovascular remodeling in ventricular tissue. These findings indicate that ISO could be a potential agent against cardiac hypertrophy and fibrosis.
- Journal
- Front Cell Dev Biol
- Publish Year
- 2020
- Experiment Subject
- human
- Experiment Type
- Cell Experiment
- Phenotype Related
- Heart Failure; Cardiovascular Diseases; Cardiac Hypertrophy; Arrhythmia; Cvds; Fibrosis; Myocardial Hypertrophy
- Paper Title Cn
- Paper Title En
- Effects of Isorhamnetin in Human Amniotic Epithelial Stem Cells in vitro and Its Cardioprotective Effects in vivo
- Bilingual Status
- semi_complete