Meta AnalysisID 963
利用普鲁兰多糖和/或右旋糖酐基材料的骨组织工程策略：一项临床前研究的系统评价
CRD42021220920
What is the benefit of using pullulan and/or dextran for bone regeneration in animal model? Context and rationale Improving bone regeneration has been and is still a challenge since these last decades. Bone resorption or
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 963
- Evidence Id
- 9521
- Core Evidence Id
- 9521
- Source Meta Analysis Id
- 934
- Herb2 Meta Analysis Id
- HBMA000934
- Crd Id
- CRD42021220920
- Title
- Bone tissue engineering strategies using pullulan and/or dextran-based materials: a systematic review of pre-clinical studies.
- Review Question
- What is the benefit of using pullulan and/or dextran for bone regeneration in animal model? Context and rationale Improving bone regeneration has been and is still a challenge since these last decades. Bone resorption or loss can occur following trauma, pathologies or tumors resection. Principles of bone reconstruction rely on the ability for a graft to perform simultaneously osteoinduction, osteoconduction and osteogenesis. The gold standard technique for bone reconstruction is still autologous bone grafting as no immune reaction occurs and it provides all the properties required for bone regeneration. But this method has some limitations due to its limited availability and inherent complications from the additional surgical procedures. Bone tissue engineering (BTE) strategies have thus emerged to develop alternatives to autologous bone graft reconstruction. BTE aims to elaborate scaffolds that mimic the mechanical and structural features of bone extracellular matrix. This approach is based on a combination of scaffolds with cells and/or bioactive molecules to provide the conditions required for bone formation namely to enable cell viability and proliferation, osteodifferentiation, angiogenesis, host integration and when needed, load bearing. Ceramics phosphate cements such as hydroxyapatite or β-tricalcium phosphate are the most commonly used scaffold for BTE applications. More recently, the additional use of natural polymers has gained interest to synthesize such scaffolds. They show great biocompatibility, biodegradability and share similar structures to the natural extracellular matrix. Polysaccharides are one type of natural polymers that must be considered. Dextran and Pulluan are polysaccharides that are already used for some medical applications. Systematic review on this topic has never been done before.
- Study Type Included
- Inclusion criteria: All in vivo preclinical studies involving pullulan alone, dextran alone or pullulan and dextran scaffolds for bone regeneration were included. Exclusion criteria: In vitro studies, clinical studies were excluded.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All animal models (all species, all sexes) presenting a bone defect or for ectopic bone formation. Exclusion criteria: in vitro models.
- Human Disease Modelled
- Bone loss reconstruction in maxillofacial surgery
- Intervention
- Inclusion criteria: Use of pullulan and/or dextran substitutes in bone regeneration procedures formation. Route of administration for local implantation of the polysaccharide substitute Exclusion criteria: when bone formation criterion is not used, in vivo studies of biomaterial degradation, when route of administration is local injection of the polysaccharide substitute, when pulullan or dextran is not used, studies are excluded.
- Comparator Control
- Inclusion criteria: All controls are accepted Exclusion criteria: No control group
- Main Outcome
- Outcome Measure
- Inclusion criteria: Bone Volume, Bone Density, Bone Mineral Content, Percentage of bone formation, Percentage of bone healing, Histomorphometric measurement, Histological analysis. Exclusion criteria: Insignificant results.
- Additional Outcome
- Study Method
- Keyword
- Animals; Bone and Bones; Dextrans; Engineering; Glucans; Tissue Engineering; pullulan
- Contact
- Naïma AHMED OMAR [email protected]
- Organisational Affiliation
- BioTis, INSERM U1026 http://www.biotis-bordeaux.com/
- Funding Source
- The Laboratory for the Bioengineering of Tissues (BioTis U1026) is a Unité Mixte de Recherche (UMR) that combines individuals from the French National Institute of Health and Medical Research (INSERM) and the Université de Bordeaux.
- Other Selection Criteria
- Inclusion criteria: Studies published between 2000 and 2020 and written in English or French were included. Exclusion criteria: Pullulan or dextran used as fluorescent tracer to study bone regeneration. Reviews were excluded.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Pre-clinical animal intervention review
- Language
- English
- Country
- France
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-11-15
- Registration Date
- 2021-05-14
- Anticipated Start Date
- 2020-10-25
- Anticipated Completion Date
- 2021-05-31
- Title Cn
- 利用普鲁兰多糖和/或右旋糖酐基材料的骨组织工程策略：一项临床前研究的系统评价
- Title En
- Bone tissue engineering strategies using pullulan and/or dextran-based materials: a systematic review of pre-clinical studies.
- Bilingual Status
- complete