Meta AnalysisID 960
大蒜素根除幽门螺杆菌：一项随机对照试验的Meta分析
CRD42019118199
To assess the effects and safety of Allicin on Helicobacter pylori eradication.
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 960
- Evidence Id
- 9518
- Core Evidence Id
- 9518
- Source Meta Analysis Id
- 932
- Herb2 Meta Analysis Id
- HBMA000932
- Crd Id
- CRD42019118199
- Title
- Allicin for helicobacter pylori eradication: a meta-analysis of randomized controlled trials
- Review Question
- To assess the effects and safety of Allicin on Helicobacter pylori eradication.
- Study Type Included
- Regardless of the length of treatment, we will include all randomised controlled trials that compare H. pylori eradication rate as well as adverse incidence rate between allicin used alone or combined with conventional treatments and conventional treatments in accordance with experiment group.
- Condition Being Studied
- Helicobacter pylori (H. pylori) is classified as class I carcinogens by the world health organization , and may cause damage to cells, resulting in clinical consequences from asymptomatic gastritis to peptic ulcer and gastric malignancies. Currently, proton-pump inhibitors or bismuth combined with two antibiotics are used to inhibit the secretion of gastric acid, protect gastric mucosa and resist H. pylori.However, it was found in clinical practice that the eradication rate of H. pylori decreased gradually due to the increased resistance of H. pylori to antibiotics such as metronidazole, clarithromycin and levofloxacin. Besides, long-term clinical use of antibiotics will lead to gastrointestinal dysfunction, gastrointestinal flora imbalance and other adverse reactions. Previous studies showed that allicin had good bacteriostatic effect on H. pylori, with a total inhibition rate of 92.2%. A growing number of clinical controlled studies have found that allicin can improve the eradication rate of H. pylori and reduce the incidence of adverse reactions, but there is no systematic review yet. Therefore, on the basis of extensive literature collection, we will conduct a meta-analysis to assess the eradication rate and incidence of adverse reactions of allicin in the treatment of H. pylori eradication.
- Participant
- The subjects included will be H. pylori infected patients.The diagnostic criteria will be consistent with one or more of the following items showing positive results: rapid urease test (RUT), 13C-ureabreath test(13CBUT), 14C-ureabreath test(14CBUT), or histology.
- Animal
- Human Disease Modelled
- Intervention
- The intervention measures in the treatment group will be allicin used alone or combined with conventional treatments.
- Comparator Control
- The control group will be treated with conventional therapy in accordance with experiment group.
- Main Outcome
- The primary outcome measure will be eradication rate of H.pylori after treatment, which will be simultaneously confirmed by one or more following items showing negative results: RUT, 13CBUT, 14CBUT, or histology.
- Outcome Measure
- Additional Outcome
- Incidence rate of adverse event.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Helicobacter Infections; Helicobacter pylori; Humans; Randomized Controlled Trials as Topic; Sulfinic Acids; allicin
- Contact
- Xiaotao Jiang [email protected]
- Organisational Affiliation
- Guangzhou univercity of Chinese Medicine http://www.gzucm.edu.cn/
- Funding Source
- Funding provided by Fengbin Liu
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2018-12-04
- Registration Date
- 2019-01-04
- Anticipated Start Date
- 2019-01-01
- Anticipated Completion Date
- 2019-08-01
- Title Cn
- 大蒜素根除幽门螺杆菌：一项随机对照试验的Meta分析
- Title En
- Allicin for helicobacter pylori eradication: a meta-analysis of randomized controlled trials
- Bilingual Status
- complete