Meta AnalysisID 959
肾素-血管紧张素-醛固酮阻断在晚期慢性肾脏病患者中的临床结局：一项系统评价与Meta分析
CRD42021261806
Does the initiation or continuation of renin-angiotensin aldosterone blockade in patients that progress to advanced chronic kidney disease (Stage 4 - 5) lead to improved cardiac and renal outcomes compared to the withdra
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 959
- Evidence Id
- 9517
- Core Evidence Id
- 9517
- Source Meta Analysis Id
- 931
- Herb2 Meta Analysis Id
- HBMA000931
- Crd Id
- CRD42021261806
- Title
- Clinical outcomes of renin-angiotensin aldosterone blockade in patient with advanced chronic kidney disease: a systematic review and meta-analysis
- Review Question
- Does the initiation or continuation of renin-angiotensin aldosterone blockade in patients that progress to advanced chronic kidney disease (Stage 4 - 5) lead to improved cardiac and renal outcomes compared to the withdrawal or non-use of renin-angiotensin aldosterone blockade?
- Study Type Included
- randomized controlled trials and observational studies with at least 6 months of follow-up
- Condition Being Studied
- Chronic kidney disease
- Participant
- Advanced Stage Chronic Kidney Disease (eGFR < 30 mL/min/1.73m^2)
- Animal
- Human Disease Modelled
- Intervention
- Initiation of renin-angiotensin aldosterone blockade Continuation of renin-angiotensin aldosterone blockade
- Comparator Control
- Avoidance of renin-angiotensin aldosterone blockade Stopping of renin-angiotensin aldosterone blockade
- Main Outcome
- Progression to end-stage renal disease, mortality, major adverse cardiovascular events Measures of effect The relative risk (RR) with associated 95% confidence intervals will be the principal summary measure.
- Outcome Measure
- Additional Outcome
- Not applicable
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Aldosterone; Angiotensins; Humans; Renal Insufficiency, Chronic; Renin; Renin-Angiotensin System
- Contact
- Nicolas Vendeville [email protected]
- Organisational Affiliation
- McGill University
- Funding Source
- Self-funded
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Canada
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-06-18
- Registration Date
- 2021-07-18
- Anticipated Start Date
- 2021-06-18
- Anticipated Completion Date
- 2021-08-31
- Title Cn
- 肾素-血管紧张素-醛固酮阻断在晚期慢性肾脏病患者中的临床结局：一项系统评价与Meta分析
- Title En
- Clinical outcomes of renin-angiotensin aldosterone blockade in patient with advanced chronic kidney disease: a systematic review and meta-analysis
- Bilingual Status
- complete