Meta AnalysisID 944
局部用肾上腺素作为止血剂及其在急救医疗环境中的作用：系统评价
CRD42022327273
What evidence is available to support or oppose the use of topical epinephrine as a haemostatic agent in external wounds, burns, or epistaxis? Sub-questions: Is this evidence sufficient to support the use of topical epin
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 944
- Evidence Id
- 9502
- Core Evidence Id
- 9502
- Source Meta Analysis Id
- 918
- Herb2 Meta Analysis Id
- HBMA000918
- Crd Id
- CRD42022327273
- Title
- Topical epinephrine (adrenaline) as a haemostatic agent and its place in paramedic settings: a systematic review
- Review Question
- What evidence is available to support or oppose the use of topical epinephrine as a haemostatic agent in external wounds, burns, or epistaxis? Sub-questions: Is this evidence sufficient to support the use of topical epinephrine as a haemostatic agent in the paramedic setting? What concentrations of topical epinephrine are most effective at achieving haemostasis in different locations of the body? What are the potential clinical or logistical limitations that can prevent paramedic use of topical epinephrine in this setting?
- Study Type Included
- All related published studies and grey literature that satisfy other inclusion criteria. Data from randomised control trials will be supplemented with observational studies, experimental studies, systematic reviews, case studies, published guidelines, and other pertinent grey literature from eminent bodies.
- Condition Being Studied
- External bleeding, haemorrhage, epistaxis, burns, trauma
- Participant
- Inclusion: patients with external bleeding, epistaxis or burns Exclusion: patients with deep internal bleeding
- Animal
- Human Disease Modelled
- Intervention
- Topical epinephrine (adrenaline) as a haemostat monotherapy
- Comparator Control
- Epinephrine used in different concentrations. Other methods of haemostatic control. Studies without comparators will also be included.
- Main Outcome
- Time to haemostasis. Volume or rate of blood loss, which can be measured by the amount of blood and blood products left on gauze swab (Groenewold et al., 2011). Groenewold, M. D., Gribnau, A. J., & Ubbink, D. T. (2011). Topical haemostatic agents for skin wounds: a systematic review. BMC Surgery, 11(15), 1-8. https://doi.org/10.1186/1471-2482-11-15
- Outcome Measure
- Additional Outcome
- Rate of wound healing, which can be measured by the proportion of re-epithelialised tissue after a specified period (Groenewold et al., 2011). Adverse effects (e.g. tachycardia, hypotension, tissue necrosis, increased infection (Korkmaz et al., 2015; List et al., 2021). Groenewold, M. D., Gribnau, A. J., & Ubbink, D. T. (2011). Topical haemostatic agents for skin wounds: a systematic review. BMC Surgery, 11(15), 1-8. https://doi.org/10.1186/1471-2482-11-15 Korkmaz, H., Yao, W. C., Korkmaz, M., & Bleier, B. S. (2015). Safety and efficacy of concentrated topical epinephrine use in endoscopic endonasal surgery. International Forum of Allergy & Rhinology, 5(12), 1118-1123. https://doi.org/10.1002/alr.21590 List, M. A., Dirain, C. O., Haberman, R. X., & Antonelli, P. J. (2021). Efficacy of topical epinephrine in tympanoplasty. The Laryngoscope, 131(10), 2319-2322. https://doi.org/10.1002/lary.29688
- Study Method
- Systematic review
- Keyword
- Allied Health Personnel; Epinephrine; Hemostatics; Humans
- Contact
- Sophia Manahan [email protected]
- Organisational Affiliation
- Charles Sturt University https://www.science.csu.edu.au
- Funding Source
- Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- Country
- Australia
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-23
- Registration Date
- 2022-05-10
- Anticipated Start Date
- 2022-04-01
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 局部用肾上腺素作为止血剂及其在急救医疗环境中的作用：系统评价
- Title En
- Topical epinephrine (adrenaline) as a haemostatic agent and its place in paramedic settings: a systematic review
- Bilingual Status
- complete