Meta AnalysisID 941
院外心脏骤停静脉与骨内肾上腺素的比较：Meta分析
CRD42020183961
The present study investigated whether intravenous and intraosseous adrenaline administration lead to different outcomes in out-of-hospital cardiac arrest.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 941
- Evidence Id
- 9499
- Core Evidence Id
- 9499
- Source Meta Analysis Id
- 914
- Herb2 Meta Analysis Id
- HBMA000914
- Crd Id
- CRD42020183961
- Title
- Intravenous versus intraosseous adrenaline administration in out-of-hospital cardiac arrest: A meta-analysis
- Review Question
- The present study investigated whether intravenous and intraosseous adrenaline administration lead to different outcomes in out-of-hospital cardiac arrest.
- Study Type Included
- Studies were considered eligible if they met the following criteria: (1) Studies that focused on intravenous versus intraosseous adrenaline administration in out-of-hospital cardiac arrest and (2) studies with complete information for the assessment of odds ratios (ORs) with 95% confidence intervals (CIs). In cases where there was overlap of the study population or enrollment period in articles published by the same investigators, the article with the greatest number of patients was used for the analysis. The exclusion criteria were as follows: (1) studies published repeatedly; (2) reviews, conference abstracts, letter, or case reports; and (3) studies without available data for statistics.
- Condition Being Studied
- Out-hospital cardiac arrest (OHCA) are a major public health concern and a leading cause of death worldwide. More than 350 000 individuals in North America and 275 000 individuals in Europe experience OHCAs annually, and only 10 % of patients who suffer from OHCA survive to discharge. Survival of patients with cardiac arrest, particularly out-of-hospital cardiac arrest, depends on quick and high-quality administration of CPR. Epinephrine is the primary drug administered during cardiopulmonary resuscitation (CPR) to reverse cardiac arrest, and early administration of epinephrine is associated with a higher probability of return of spontaneous circulation (ROSC). In the current guidelines, intraosseous is recommended as a rescue device if iv access cannot be obtained in cases of cardiac arrest. Some studies assessed intravenous versus intraosseous adrenaline administration in OHCA; however, the results seemed to be conflicting. Therefore, here we further performed an updated meta-analysis to evaluate whether intravenous and intraosseous adrenaline administration lead to different outcomes in OHCA.
- Participant
- Out-hospital cardiac arrestpatients who received prehospital adrenaline.
- Animal
- Human Disease Modelled
- Intervention
- intravenous adrenaline administration
- Comparator Control
- intraosseous adrenaline administration
- Main Outcome
- prehospital eturn of spontaneous circulation, survival and favorable neurological outcome. Measures of effect The OR was used to denote the results with a 95% CI, indicating the strength of association between treatments and outcomes.
- Outcome Measure
- Additional Outcome
- No Measures of effect No
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Cardiopulmonary Resuscitation; Epinephrine; Humans; Infusions, Intraosseous; Out-of-Hospital Cardiac Arrest
- Contact
- Shun Yi Feng [email protected]
- Organisational Affiliation
- Cangzhou Central Hosptial
- Funding Source
- No funding sources
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-05-03
- Registration Date
- 2020-07-05
- Anticipated Start Date
- 2020-05-10
- Anticipated Completion Date
- 2021-01-01
- Title Cn
- 院外心脏骤停静脉与骨内肾上腺素的比较：Meta分析
- Title En
- Intravenous versus intraosseous adrenaline administration in out-of-hospital cardiac arrest: A meta-analysis
- Bilingual Status
- complete