Meta AnalysisID 939
肾上腺素的给药时机、途径和剂量
CRD42019132219
Among neonates (of any gestation) ≤ 28 days of age who have no detected cardiac output or who have asystole or heart rate < 60 bpm despite ventilation and chest compressions, does any non-standard dose, interval or ro
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 939
- Evidence Id
- 9497
- Core Evidence Id
- 9497
- Source Meta Analysis Id
- 912
- Herb2 Meta Analysis Id
- HBMA000912
- Crd Id
- CRD42019132219
- Title
- Timing, route and dose of epinephrine (adrenaline)
- Review Question
- Among neonates (of any gestation) ≤ 28 days of age who have no detected cardiac output or who have asystole or heart rate < 60 bpm despite ventilation and chest compressions, does any non-standard dose, interval or route (e.g. IO or ETT etc.) of epinephrine (adrenaline), compared to standard dose intravenous epinephrine (adrenaline) (0.01-0.03 mg/kg) at intervals of every 3-5 minutes, improve the primary outcome (survival at discharge) as well as any secondary outcomes?
- Study Type Included
- Included: • Randomized controlled trials (RCTs) • Non-randomized studies: non-randomized controlled trials, interrupted time series, controlled before-and-after studies, and cohort studies are eligible for inclusion. • All languages as long as there is an English abstract Excluded: • Unpublished studies (e.g., conference abstracts, trial protocols)* • Case series that cannot provide the estimate of incidence of outcomes • Animal studies
- Condition Being Studied
- Neonates (≤ 28 days) Standard dose epinephrine is 0.01-0.03 mg/kg per dose via intravenous route. Cardiac arrest or severe bradycardia (< 60 bpm)
- Participant
- Inclusion criteria: Neonates (of any gestation) within 28 days of age who have no detected cardiac output or who have asystole or heart rate < 60 bpm despite ventilation and chest compressions Exclusion criteria: Neonates who do not receive active resuscitation (palliative care only), Stillbirths
- Animal
- Human Disease Modelled
- Intervention
- Epinephrine (adrenaline) at any non-standard dose or intervals, or via any non-standard routes (e.g. IO or ETT etc.)
- Comparator Control
- Epinephrine (adrenaline) at standard dose (0.01-0.03 mg/kg) at intervals of every 3-5 minutes via intravenous route
- Main Outcome
- Mortality as defined by study authors Measures of effect Mortality as defined by study authors
- Outcome Measure
- Additional Outcome
- Return of spontaneous circulation (ROSC*) “incidence and time until” HIE Stage moderate-severe (term only) IVH Grades III-IV (preterm only) Other morbidities in early infancy (e.g., necrotizing enterocolitis, retinopathy of prematurity, bronchopulmonary dysplasia, periventricular leukomalacia) Neurodevelopmental outcomes Measures of effect *ROSC is defined as the restoration of a spontaneous perfusing rhythm that results in more than an occasional gasp, fleeting palpated pulse, or arterial waveform.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Epinephrine; Humans
- Contact
- Tetsuya Isayama [email protected]
- Organisational Affiliation
- International Liaison Committee on Resuscitation http://www.ilcor.org
- Funding Source
- This Systematic Review was funded by the American Heart Association, on behalf of The International Liaison Committee on Resuscitation (ILCOR) for manuscript submission to the editor. The following investigators/institutions received payment from this funding source to complete this systematic review: Tetsuya Isayama as Expert Systematic Reviewer St. Michael’s Hospital Health Sciences Library; our information specialist, Carolyn Ziegler, did not receive compensation.
- Other Selection Criteria
- Final Publication
- Isayama T, Mildenhall L, Schmölzer GM, Kim HS, Rabi Y, Ziegler C, Liley HG; INTERNATIONAL LIAISON COMMITTEE ON RESUSCITATION NEWBORN LIFE SUPPORT TASK FORCE. The Route, Dose, and Interval of Epinephrine for Neonatal Resuscitation: A Systematic Review. Pediatrics. 2020 Oct;146(4):e20200586. doi: 10.1542/peds.2020-0586. Epub 2020 Sep 9. PMID: 32907923.
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia, Canada, Japan, New Zealand, South Korea
- Review Stage
- Review Completed published
- First Submission Date
- 2019-06-16
- Registration Date
- 2019-08-22
- Anticipated Start Date
- 2019-02-19
- Anticipated Completion Date
- 2019-09-08
- Title Cn
- 肾上腺素的给药时机、途径和剂量
- Title En
- Timing, route and dose of epinephrine (adrenaline)
- Bilingual Status
- complete