Meta AnalysisID 938
自动注射器给予肾上腺素用于过敏反应的药代动力学和药效学证据：系统评价
CRD42019119926
What is the pharmacokinetic and pharmacodynamic evidence underlying the dosing administration recommendations for adrenaline, using an auto-injector, for anaphylactic reactions?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 938
- Evidence Id
- 9496
- Core Evidence Id
- 9496
- Source Meta Analysis Id
- 911
- Herb2 Meta Analysis Id
- HBMA000911
- Crd Id
- CRD42019119926
- Title
- Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto-injector for anaphylactic reactions: a systematic review
- Review Question
- What is the pharmacokinetic and pharmacodynamic evidence underlying the dosing administration recommendations for adrenaline, using an auto-injector, for anaphylactic reactions?
- Study Type Included
- All types of study design will be eligible for inclusion in the review. However, review articles, letters, editorials, conference abstracts and opinion articles will be excluded. Our inclusion criteria are: - Report the use of adrenaline intramuscularly for the treatment of anaphylaxis - Detail the injection method or device, - Specify the needle length Our exclusion criteria are: - Non-human studies - Adrenaline given by other routes - Not given for anaphylaxis - Review articles, letter, editorials, conference abstracts and opinion articles - Articles not in English
- Condition Being Studied
- Treatment of anaphylaxis using an adrenaline auto-injector.
- Participant
- The review will focus on all humans given adrenaline by intramuscular injection for the treatment of anaphylaxis. There will be no age restriction placed. All non-human studies will be excluded.
- Animal
- Human Disease Modelled
- Intervention
- The intervention being reviewed is the use of adrenaline for anaphylaxis which is delivered via an auto-injector device.
- Comparator Control
- Not applicable.
- Main Outcome
- - Effective treatment of anaphylaxis - Treatment failure (anaphylaxis not treated) There is no specified definition that we will use for what is considered 'effective treatment of anaphylaxis' or 'treatment failure'. This is usually made by the clinician seeing the patient and we will have to consider this during the review. Measures of effect Not applicable.
- Outcome Measure
- Additional Outcome
- - Needle length associated with treatment failure - Adverse events. Measures of effect Not applicable.
- Study Method
- Narrative synthesis, Systematic review
- Keyword
- Anaphylaxis; Diagnostic Tests, Routine; Epinephrine; Humans
- Contact
- James Moss [email protected]
- Organisational Affiliation
- Alder Hey Children's NHS Foundation Trust, Liverpool Guy's and St Thomas' NHS Foundation Trust, London Kings College London University College London Hospitals NHS Foundation Trust
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Moss, J, Jani, Y, Edwards, B, Tomlin, S, Rashed, AN. Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto‐injector for anaphylactic reactions: A review of literature. Br J Clin Pharmacol. 2020; 1– 9. https://doi.org/10.1111/bcp.14438 https://bpspubs.onlinelibrary.wiley.com/doi/full/10.1111/bcp.14438
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- England
- Review Stage
- Review Completed published
- First Submission Date
- 2019-03-05
- Registration Date
- 2019-04-15
- Anticipated Start Date
- 2018-12-05
- Anticipated Completion Date
- 2019-04-24
- Title Cn
- 自动注射器给予肾上腺素用于过敏反应的药代动力学和药效学证据：系统评价
- Title En
- Pharmacokinetic and pharmacodynamic evidence of adrenaline administered via auto-injector for anaphylactic reactions: a systematic review
- Bilingual Status
- complete