Meta AnalysisID 928
含木糖醇产品对龋病的效果：系统评价与网状Meta分析
CRD42020168945
Can xylitol-containing products prevent dental caries?
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Record Fields
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- Meta Analysis Id
- 928
- Evidence Id
- 9486
- Core Evidence Id
- 9486
- Source Meta Analysis Id
- 902
- Herb2 Meta Analysis Id
- HBMA000902
- Crd Id
- CRD42020168945
- Title
- Effect of xylitol-containing products on dental caries: A systematic review and network meta-analysis
- Review Question
- Can xylitol-containing products prevent dental caries?
- Study Type Included
- Parallel-design Randomized clinical trial (RCT)
- Condition Being Studied
- Based on WHO, dental caries is one of the most prevalent diseases in the world, and described as a biofilm-mediated, diet modulated, multifactorial, non-communicable, dynamic disease resulting in net mineral loss of dental hard tissues according to a 2020 ORCA consensus statement. It is determined by biological, behavioral, psychosocial, and environmental factors; consequently, a caries lesion develops as a result of this process. However, several bacteria have been involved in the caries process, and Streptococcus mutants have been identified as the primary pathogen. Xylitol is a natural sugar alcohol but is not fermented by oral microbes; therefore, is considered non-acidogenic and has a potential anticaries impact.
- Participant
- Healthy individuals irrespective of age and sex
- Animal
- Human Disease Modelled
- Intervention
- Xylitol-containing products (i.e. products used xylitol as natural sweetener such as candies, chewing gum, candy, mouthwash, and toothpaste)
- Comparator Control
- Any control intervention (i.e. control, placebo, other sugar alcohols such as sucrose, sorbitol, erythritol, sorbitol, and other interventions such as fluoride, etc.)
- Main Outcome
- 1- Primary outcome: Caries progression 2- Secondary outcome: Salivary/plaque levels of cariogenic pathogen (Streptococcus mutans) Measures of effect 1- Primary outcome: The number of new carious lesions compared with baseline measured by caries indices as DMFT/S, dmft/s, ICDAS, etc. 2- Secondary outcome: The total values of Colony Forming Unit (CFU) in the last follow-up compared with baseline values.
- Outcome Measure
- Additional Outcome
- If information on the following is available, we will include for further analysis: 1- Salivary/plaque pH 2- Plaque quantification (using plaque index) Measures of effect By comparing the baseline values to the effects of the endpoint
- Study Method
- Network meta-analysis, Prevention, Systematic review
- Keyword
- Dental Caries; Humans; Network Meta-Analysis; Xylitol
- Contact
- Ahmad G. A. Khater [email protected]
- Organisational Affiliation
- Ahram Canadian University http://www.acu.edu.eg/ar/
- Funding Source
- No funding sources/sponsors
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Egypt
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-02-15
- Registration Date
- 2020-07-10
- Anticipated Start Date
- 2020-02-17
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 含木糖醇产品对龋病的效果：系统评价与网状Meta分析
- Title En
- Effect of xylitol-containing products on dental caries: A systematic review and network meta-analysis
- Bilingual Status
- complete