Meta AnalysisID 925
再矿化剂（CPP-ACP/生物活性玻璃或NOVAMIN/臭氧/木糖醇）联合局部氟化物与单用局部氟化物防龋和再矿化效果比较的系统评价与Meta分析
CRD42020150746
Population: Human subjects with incipient lesions/cavitated/non-cavitated lesions. Intervention: Remineralizing agent (CPP-ACP/Bioactive glass/ Ozone/ Xylitol) and Topical Fluoride Control: Topical Fluoride alone Outcome
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 925
- Evidence Id
- 9483
- Core Evidence Id
- 9483
- Source Meta Analysis Id
- 899
- Herb2 Meta Analysis Id
- HBMA000899
- Crd Id
- CRD42020150746
- Title
- A systematic review and meta-analysis to compare caries preventing and remineralising potential of combined therapy using a remineralising agent (CPP-ACP/ Bioactive Glass or NOVAMin/ Ozone/ Xylitol) and topical fluoride versus topical fluoride alone
- Review Question
- Population: Human subjects with incipient lesions/cavitated/non-cavitated lesions. Intervention: Remineralizing agent (CPP-ACP/Bioactive glass/ Ozone/ Xylitol) and Topical Fluoride Control: Topical Fluoride alone Outcome: Remineralization potential (laser fluorescence readings); Caries preventive effect (caries increment & S mutans Count) Studies: Randomized controlled trials
- Study Type Included
- Randomised controlled trials
- Condition Being Studied
- The progression or reversal of dental caries depends on to which side the equilibrium between demineralization-remineralization shifts. Pathological factors like presence of cariogenic bacteria, fermentable carbohydrates and salivary dysfunction promotes tooth demineralization. On the other hand, protective factors like administration of antibacterial agents, presence of sufficient saliva and remineralizing ions promotes tooth remineralization. The principles of minimally invasive dentistry advocates the use of clinically effective measures to remineralize lesions at an early stage. While fluoride-mediated remineralization is the cornerstone of current caries management regimens, a number of new remineralization agents have been commercialized in order to promote deeper remineralization of lesions and thus facilitating caries control over a lifetime. Clinical trials assessing the effectiveness of combined use of CPP-ACP/ Xylitol/ Ozone/ Bioactive glass and topical fluoride have been reported but with no conclusive evidence.
- Participant
- Humans with fully erupted primary and/or permanent dentition.
- Animal
- Human Disease Modelled
- Intervention
- Combined use of remineralizing agent (CPP-ACP/Bioactive glass/ Ozone/ Xylitol) and topical fluoride
- Comparator Control
- Topical fluoride alone
- Main Outcome
- Change on demineralized tooth status; Measures of effect Remineralization potential using laser fluorescence readings at a minimum follow up of 30 days.
- Outcome Measure
- Additional Outcome
- Dental caries Increment assessed using new decayed teeth/surfaces; Post-treatment S. mutans count. Measures of effect Dental caries increment assessed using new decayed teeth/surfaces at a minimum follow up of one year; Post-treatment S. mutans count at a minimum follow up of 4 weeks.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- 6-chloro-2-(1-piperazinyl)pyrazine; Caseins; Dental Caries; Fluorides, Topical; Humans; NovaMin; Ozone; Xylitol; casein phosphopeptide-amorphous calcium phosphate nanocomplex
- Contact
- Arpit Gupta [email protected]
- Organisational Affiliation
- Postgraduate Institute of Medical Education & Research, Chandigarh, India www.pgimer.edu.in
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-10-12
- Registration Date
- 2020-03-19
- Anticipated Start Date
- 2019-09-01
- Anticipated Completion Date
- 2019-11-10
- Title Cn
- 再矿化剂（CPP-ACP/生物活性玻璃或NOVAMIN/臭氧/木糖醇）联合局部氟化物与单用局部氟化物防龋和再矿化效果比较的系统评价与Meta分析
- Title En
- A systematic review and meta-analysis to compare caries preventing and remineralising potential of combined therapy using a remineralising agent (CPP-ACP/ Bioactive Glass or NOVAMin/ Ozone/ Xylitol) and topical fluoride versus topical fluoride alone
- Bilingual Status
- complete