Meta AnalysisID 919
腺苷拮抗剂预防新生儿围产期窒息后急性肾损伤：系统评价与Meta分析
CRD42020161820
Adenosine antagonists for prevention of acute kidney injury post neonatal perinatal asphyxia: a systematic review and meta-analysis
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Record Fields
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- Meta Analysis Id
- 919
- Evidence Id
- 9477
- Core Evidence Id
- 9477
- Source Meta Analysis Id
- 891
- Herb2 Meta Analysis Id
- HBMA000891
- Crd Id
- CRD42020161820
- Title
- Adenosine antagonists for prevention of acute kidney injury post neonatal perinatal asphyxia: a systematic review and meta-analysis
- Review Question
- Adenosine antagonists for prevention of acute kidney injury post neonatal perinatal asphyxia: a systematic review and meta-analysis
- Study Type Included
- Randomized or quasi-randomized controlled trials
- Condition Being Studied
- Asphyxia remains a common problem in the neonatal nursery and is a significant cause of morbidity and death in the term and preterm neonate.Acute kidney injury (AKI) is a common consequence of perinatal asphyxia, which occurs in 56% of these infants.Despite increased mortality, there are few modalities for prevention and treatment of AKI.The goal of early treatment is to prevent or treat predicable complications. Adenosine plays an important role in the kidney. During perinatal asphyxia, hypoxia or ischemia can activate adenosine receptors in renal tubules and endothelial cells, which improved ischemia-reperfusion injury by regulating metabolic demand, reducing necrosis, apoptosis and inflammation. Adenosine antagonists such as theophylline may be beneficial to the renal perfusion.Some clinical trials have shown the benefit of adenosine antagonists in reducing the AKI caused by perinatal hypoxic-ischemic insult in recent years.A systematic review and meta-analysis are needed to understand the strength of evidence, limitations and to identify its clinical utility in the current era.
- Participant
- All neonates with perinatal asphyxia who received adenosine antagonists are eligible. Exclusion criteria: small for gestational age (SGA), KUB anomaly, polycythemia, chromosomal disorders, history of tachyarrhythmias, seizures, and drug intake by mother causing depression , parent of subject did not agreed or quit to study.
- Animal
- Human Disease Modelled
- Intervention
- Intervention: All enrolled infants will be randomized to a single dose of intravenous adenosine antagonist or placebo within the first hour of life. Definition of AKI would be taken as per the definition used in the individual study.
- Comparator Control
- Placebo or no intervention.
- Main Outcome
- To evaluate the incidence of AKI , Serum creatinine levels and mortality. Measures of effect Develoment of AKI within a time frame of 5 or 7 days would be included. Serum creatinine levels during initial 5 or 7 days.
- Outcome Measure
- Additional Outcome
- 1)To evaluate metabolic disturbance, total fluid balance, inotropics required, duration of mechanical ventilation and hospital stay. 2)To evaluate renal tubular and glomerular function, including urine beta2 microglobulin, glomerular filtration rate. 3)Complications Measures of effect Electrolyte and acid-base balance, total fluid balance, inotropics required, duration of mechanical ventilation，hospital stay，urine beta2 microglobulin, glomerular filtration rate and complications during initial 5 or 7 days.
- Study Method
- Keyword
- Humans
- Contact
- Liu TaiXiang [email protected]
- Organisational Affiliation
- THE CHILDREN’S HOSPITAL, ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE, NATIONAL CLINICAL RESEARCH CENTER FOR CHILD HEALTH
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2019-12-10
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-12-31
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 腺苷拮抗剂预防新生儿围产期窒息后急性肾损伤：系统评价与Meta分析
- Title En
- Adenosine antagonists for prevention of acute kidney injury post neonatal perinatal asphyxia: a systematic review and meta-analysis
- Bilingual Status
- complete