Meta AnalysisID 918
胸腔积液非刺激干扰素-γ与腺苷脱氨酶诊断结核性胸膜炎的准确性比较：纳入配对数据研究的系统评价与Meta分析
CRD42020222609
Is pleural fluid unstimulated interferon-gamma assay more accurate at diagnosing pleural tuberculosis, as compared to pleural fluid adenosine deaminase assay, among patients being evaluated for etiology of pleural effusi
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 918
- Evidence Id
- 9476
- Core Evidence Id
- 9476
- Source Meta Analysis Id
- 890
- Herb2 Meta Analysis Id
- HBMA000890
- Crd Id
- CRD42020222609
- Title
- Comparative diagnostic accuracy of pleural fluid unstimulated interferon-gamma and adenosine deaminase for diagnosing pleural tuberculosis: a systematic review and meta-analysis of studies providing paired data
- Review Question
- Is pleural fluid unstimulated interferon-gamma assay more accurate at diagnosing pleural tuberculosis, as compared to pleural fluid adenosine deaminase assay, among patients being evaluated for etiology of pleural effusion?
- Study Type Included
- Studies having patients of both tuberculous and non-tuberculous pleural effusions and reporting on diagnostic performance of both pleural fluid unstimulated interferon gamma and pleural fluid adenosine deaminase levels in the same study population .
- Condition Being Studied
- Tuberculous pleural effusion is one of the commonest extra-pulmonary sites of tuberculosis. Because it is a hypersensitivity phenomenon to tubercular antigens in the pleural space, rather than a pure infection, microbiological confirmation is uncommon in most instances. Pleural biopsy may provide a diagnosis but is an invasive procedure. Clinicians often rely on other indirect biochemical on pleural fluid, and other clinical and pleural fluid characteristics, to arrive at a clinical diagnosis and start treatment. Pleural fluid adenosine deaminase assay is a widely used investigation for this purpose. More recently, pleural fluid interferon gamma levels have been shown to be a useful discriminator as well. However, there is no clear information on the comparative accuracy of adenosine deaminase and interferon-gamma for this purpose. A diagnostic test that more accurately suggests diagnosis of tuberculosis will avoid unnecessary further investigations in these patients. Similarly, more accurate exclusion of tuberculosis will avoid unnecessary prescriptions of empiric anti-tubercular treatment.
- Participant
- Inclusion: Patients undergoing evaluation to determine etiology of pleural effusion. Exclusion: Nothing specific.
- Animal
- Human Disease Modelled
- Intervention
- Measurement of pleural fluid levels of unstimulated interferon gamma and adenosine deaminase in the same study population
- Comparator Control
- Positivity and negativity of pleural fluid assay results for both index tests will be computed among patients with tuberculous and non-tuberculous effusions and then compared between the two tests
- Main Outcome
- The main outcomes will be the summary diagnostic accuracy (expressed as sensitivity, specificity and diagnostic odds ratio) of both pleural fluid adenosine deaminase and interferon gamma in identifying tuberculous pleural effusion, and results of meta-regression of the hierarchical summary ROC model using test type as a covariate. Measures of effect Summary sensitivity, Summary specificity and Summary diagnostic odds ratio for the individual tests, and the summary relative diagnostic odds ratio (RDOR) for the comparative analysis
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Diagnostic, Meta-analysis, Systematic review
- Keyword
- Adenosine Deaminase; Humans; Interferon-gamma; Pleural Effusion; Sensitivity and Specificity; Tuberculosis, Pleural
- Contact
- Ashutosh Nath Aggarwal [email protected]
- Organisational Affiliation
- Postgraduate Institute of Medical Education and Research, Chandigarh www.pgimer.edu.in
- Funding Source
- No funding Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Not applicable
- Other Selection Criteria
- Final Publication
- Aggarwal AN, Agarwal R, Dhooria S, Prasad KT, Sehgal IS, Muthu V. Comparative accuracy of pleural fluid unstimulated interferon-gamma and adenosine deaminase for diagnosing pleural tuberculosis: A systematic review and meta-analysis. PLoS One. 2021 Jun 24;16(6):e0253525. https://doi.org/10.1371/journal.pone.0253525
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- India
- Review Stage
- Review Completed published
- First Submission Date
- 2020-11-25
- Registration Date
- 2020-12-26
- Anticipated Start Date
- 2020-11-30
- Anticipated Completion Date
- 2020-12-31
- Title Cn
- 胸腔积液非刺激干扰素-γ与腺苷脱氨酶诊断结核性胸膜炎的准确性比较：纳入配对数据研究的系统评价与Meta分析
- Title En
- Comparative diagnostic accuracy of pleural fluid unstimulated interferon-gamma and adenosine deaminase for diagnosing pleural tuberculosis: a systematic review and meta-analysis of studies providing paired data
- Bilingual Status
- complete