Meta AnalysisID 915
乳酸脱氢酶/腺苷脱氨酶比值鉴别结核性胸腔积液与肺炎旁胸腔积液的诊断准确性：系统评价与Meta分析
CRD42022359917
What is the diagnostic accuracy of lactate dehydrogenase/adenosine deaminase ratio in differentiating tuberculous pleural effusion and parapneumonic effusion?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 915
- Evidence Id
- 9473
- Core Evidence Id
- 9473
- Source Meta Analysis Id
- 888
- Herb2 Meta Analysis Id
- HBMA000888
- Crd Id
- CRD42022359917
- Title
- Diagnostic accuracy of lactate dehydrogenase/adenosine deaminase ratio in differentiating tuberculous pleural effusion and parapneumonic effusion: a systematic review and meta-analysis
- Review Question
- What is the diagnostic accuracy of lactate dehydrogenase/adenosine deaminase ratio in differentiating tuberculous pleural effusion and parapneumonic effusion?
- Study Type Included
- Studies of patients having both tuberculous and parapneumonic pleural effusions and reporting on diagnostic performance of pleural fluid lactate dehydrogenase/adenosine deaminase ratio. Observational studies (cross-sectional, cohort and case–control studies) will be included.
- Condition Being Studied
- Microbiological confirmation of tuberculous pleural effusion is often challenging and diagnosis often relies on pleural fluid biochemical characteristics or histopathological findings via invasive biopsy methods. Pleural fluid adenosine deaminase has been shown to correlate with a diagnosis of tuberculosis, but as a standalone test may be raised in other pleural infection. Parapneumonic effusion may present in a similar way to tuberculous effusion. More recently, pleural lactate dehydrogenase to adenosine deaminase ratio was explored as a discriminator between tuberculous and parapneumonic effusion. However, there is no clear data on the diagnostic accuracy of the lactate dehydrogenase/adenosine deaminase ratio for this purpose.
- Participant
- Patients with pleural effusion
- Animal
- Human Disease Modelled
- Intervention
- Measurement of pleural fluid lactate dehydrogenase/adenosine deaminase ratio
- Comparator Control
- Parapneumonic effusion
- Main Outcome
- Summary diagnostic accuracy (sensitivity, specificity, diagnostic odds ratio) of pleural fluid lactate dehydrogenase/adenosine deaminase ratio in differentiating tuberculous pleural effusion from parapneumonic effusion. Measures of effect Summary sensitivity, summary specificity and summary diagnostic odds ratio for the individual tests, and the summary relative diagnostic odds ratio (RDOR) for the comparative analysis
- Outcome Measure
- Additional Outcome
- Study Method
- Diagnostic, Meta-analysis, Systematic review
- Keyword
- Adenosine Deaminase; Humans; Lactate Dehydrogenases; Pleural Effusion; Tuberculosis, Pleural
- Contact
- Larry Ellee ak Nyanti [email protected]
- Organisational Affiliation
- Universiti Malaysia Sabah (Faculty of Medicine and Health Sciences) https://www.ums.edu.my/fpsk/component/content/
- Funding Source
- This review is not funded Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> Not applicable
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Malaysia
- Review Stage
- Review Completed not published
- First Submission Date
- 2022-09-13
- Registration Date
- 2022-09-24
- Anticipated Start Date
- 2022-09-30
- Anticipated Completion Date
- 2022-12-31
- Title Cn
- 乳酸脱氢酶/腺苷脱氨酶比值鉴别结核性胸腔积液与肺炎旁胸腔积液的诊断准确性：系统评价与Meta分析
- Title En
- Diagnostic accuracy of lactate dehydrogenase/adenosine deaminase ratio in differentiating tuberculous pleural effusion and parapneumonic effusion: a systematic review and meta-analysis
- Bilingual Status
- complete