Meta AnalysisID 913

腹水腺苷脱氨酶诊断结核性腹膜炎的准确性：系统评价与Meta分析

CRD42022341909

What is the diagnostic accuracy of Ascitic fluid adenosine deaminase level for diagnosis of tuberculous peritonitis.

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Meta Analysis Id: 913
Evidence Id: 9471
Core Evidence Id: 9471
Source Meta Analysis Id: 886
Herb2 Meta Analysis Id: HBMA000886
Crd Id: CRD42022341909
Title: Diagnostic test accuracy of ascitic fluid adenosine deaminase for tuberculous peritonitis: A systematic review and meta-analysis
Review Question: What is the diagnostic accuracy of Ascitic fluid adenosine deaminase level for diagnosis of tuberculous peritonitis.
Study Type Included: Studies, 1.Reporting sufficient data to determine pooled sensitivity and pooled specificity for the diagnosis of tuberculous peritonitis. 2.Reporting data in English language. 3. conducted in age groups more than eighteen years. 4. Published as full text article. 5. cross-sectional studies 6. observational studies 7. case-control studies etc.
Condition Being Studied: Tuberculous peritonitis is the most common cause of low albumin gradient ascites in developing countries, but it is difficult to differentiate it from other causes of ascites. It is important to diagnose this disease early and to initiate appropriate treatment to prevent adverse complications. Measurement of adenosine deaminase (ADA) level in ascitic fluid is an established test to diagnose tuberculous peritonitis. It has proved to become a useful non-culture method of detecting peritoneal tuberculosis. Earlier meta-analysis has shown that ADA levels had high sensitivity and specificity for the diagnosis of tuberculous peritonitis. After the publication of the earlier meta-analysis, many newer articles have been added in the literature which arises the need for updating the current data. Therefore, we aimed to conduct an updated meta-analysis to determine the diagnostic accuracy of ascitic fluid ADA for diagnosis of tuberculous peritonitis.
Participant: Studies in which patients have clinical features of peritonitis with suspected tubercular etiology. The inclusion criteria for the studies will be 1.Reporting sufficient data to determine pooled sensitivity and pooled specificity for the diagnosis of tuberculous peritonitis from non-tubercular peritonitis. 2.Reporting data in English language. 3. conducted in age more than eighteen years. 4. Published as full text article. Exclusion criteria will be 1. Editorial, 2. Case report, 3. Conference proceeding, 4. pre-print letter to editor.
Animal
Human Disease Modelled
Intervention: Ascitic fluid adenosine deaminase level (ADA) in acute phase.
Comparator Control: culture positive
Main Outcome: Diagnostic accuracy, pooled sensitivity, pooled specificity, area under the curve. Measures of effect Pooled sensitivity, pooled specificity, summary area under the curve, diagnostic odds ratio with 95% CI.
Outcome Measure
Additional Outcome: None Measures of effect None
Study Method: Meta-analysis, Systematic review
Keyword: Adenosine Deaminase; Ascites; Ascitic Fluid; Diagnostic Tests, Routine; Humans; Peritonitis, Tuberculous
Contact: Mayank Mahajan [email protected]
Organisational Affiliation: Rajendra Institute of Medical Sciences www.rimsranchi.ac.in
Funding Source: Nil
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language
Country: India
Review Stage: Review Ongoing
First Submission Date: 2022-06-28
Registration Date: 2022-07-09
Anticipated Start Date: 2022-07-01
Anticipated Completion Date: 2022-10-31
Title Cn: 腹水腺苷脱氨酶诊断结核性腹膜炎的准确性：系统评价与Meta分析
Title En: Diagnostic test accuracy of ascitic fluid adenosine deaminase for tuberculous peritonitis: A systematic review and meta-analysis
Bilingual Status: complete