Meta AnalysisID 912
腺苷辅助治疗急性冠状动脉综合征患者：少即是多——26项随机对照试验的更新Meta分析
CRD42022339582
To compare intracoronary or endovenous adenosine versus placebo, as adjunctive therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 912
- Evidence Id
- 9470
- Core Evidence Id
- 9470
- Source Meta Analysis Id
- 885
- Herb2 Meta Analysis Id
- HBMA000885
- Crd Id
- CRD42022339582
- Title
- Adenosine as adjunctive therapy in patients with acute coronary syndrome: when less is more. Updated meta-analysis of 26 randomized controlled trials.
- Review Question
- To compare intracoronary or endovenous adenosine versus placebo, as adjunctive therapy in patients with acute coronary syndrome undergoing percutaneous coronary intervention.
- Study Type Included
- Inclusion criteria are as follows: (a) randomized controlled trial design; (b) available published full text article; (c) comparison between adenosine and placebo administration in patients undergoing percutaneous coronary intervention (PCI) for acute coronary syndromes (ACS), including rescue PCIs; (e) data on at least one of the following are required: clinical outcomes including rate of major adverse cardiovascular events (MACE) and/or heart failure; surrogate endpoints of ventricular function and/or myocardial perfusion. We will exclude studies comparing different drugs administration or those comparing adenosine administration with both medical and procedural specific intervention, those enrolling patients who undergo elective PCI. No language restriction will be applied.
- Condition Being Studied
- Acute coronary syndromes. Percutaneous coronary intervention.
- Participant
- Patients with acute coronary syndromes undergoing percutaneous coronary intervention.
- Animal
- Human Disease Modelled
- Intervention
- Use of intracoronary or intravenous adenosine administration with different dosages and timing.
- Comparator Control
- Placebo.
- Main Outcome
- Primary outcomes consist in rate of clinical events and comprehend the following: heart failure (defined as both heart failure during the initial hospitalization or rehospitalization for heart failure), Major Adverse Cardiovascular Outcomes (MACE, whose definition is derived from definitions used in each study), all-cause-death and non-fatal myocardial infarction. Measures of effect Risk Ratio (RR) with 95% confidence intervals for discrete variables, hedge’s g for continuous variables and p values will be used as the summary statistic.
- Outcome Measure
- Additional Outcome
- Secondary outcomes consist in: ejection fraction (measured by different imaging techniques), ST-resolution (defined as 12-derivations ECG ST resolution > 50% within the first 24 hours after PCI), infarct size (defined as percentage of infarct area assessed by both myocardial scintigraphy and magnetic resonance), rate of final Myocardial Blush Grade (MBG) 0-1, rate of final Thrombolysis In Myocardial Infarction (TIMI) flow grade 3. We finally consider as safety endpoints the rate of advanced atrio-ventricular block, symptomatic bradicardia, ventricular fibrillation and sustained ventricular tachycardia. Measures of effect Risk Ratio (RR) with 95% confidence intervals for discrete variables, hedge’s g for continuous variables and p values will be used as the summary statistic.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Acute Coronary Syndrome; Adenosine; Humans; Randomized Controlled Trials as Topic
- Contact
- Emiliano Bianchini [email protected]
- Organisational Affiliation
- Department of Cardiovascular Sciences, Fondazione Policlinico Universitario A. Gemelli IRCCS, Università Cattolica Sacro Cuore, Rome, Italy.
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Italy
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-06-13
- Registration Date
- 2022-06-24
- Anticipated Start Date
- 2022-06-05
- Anticipated Completion Date
- 2022-07-12
- Title Cn
- 腺苷辅助治疗急性冠状动脉综合征患者：少即是多——26项随机对照试验的更新Meta分析
- Title En
- Adenosine as adjunctive therapy in patients with acute coronary syndrome: when less is more. Updated meta-analysis of 26 randomized controlled trials.
- Bilingual Status
- complete