Meta AnalysisID 905
α7烟碱型乙酰胆碱受体亚基在外周组织能量稳态调节中的作用：系统评价
CRD42021245939
How does alpha7 nicotinic acetylcholine receptor subunit modulate energy homeostasis through peripheric tissues? Context and rationale Nicotinic cholinergic receptors have an important role in classic anti-inflammatory r
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 905
- Evidence Id
- 9463
- Core Evidence Id
- 9463
- Source Meta Analysis Id
- 880
- Herb2 Meta Analysis Id
- HBMA000880
- Crd Id
- CRD42021245939
- Title
- Role of alpha7 nicotinic acetylcholine receptor subunit on modulation of energy homeostasis in peripheral tissues: a systematic review
- Review Question
- How does alpha7 nicotinic acetylcholine receptor subunit modulate energy homeostasis through peripheric tissues? Context and rationale Nicotinic cholinergic receptors have an important role in classic anti-inflammatory responses including some diseases such as irritable bowel syndrome, colitis and sepsis. However, recent studies have shown that nicotinic receptors subunits (e.g. a7nAChR) are also involved in energy homeostasis maintenance through modulation of peripheral and central tissues actions. In liver, for example, alpha7 nicotinic cholinergic receptor subunit can act inhibiting enzymes related to gluconeogenesis and affecting insulin sensibility. While in hypothalamus, these subunit has a relevant role in energetic homeostasis maintenance through modulation of anorexigenic or orexigenic neuropeptides. Therefore, it is interesting to fully comprehend alpha7 nicotinic cholinergic receptors subunit action on peripheric tissues as they can be used as pharmacological target on obesity and other comorbidities management.
- Study Type Included
- Inclusion criteria: Experimental studies in animals Exclusion criteria: None
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: Animals from Rodentia order (both sex) Exclusion criteria: None
- Human Disease Modelled
- Nicotinic cholinergic receptors have an important role in classic anti-inflammatory responses including some diseases such as irritable bowel syndrome, colitis and sepsis. Recently studies showed that some subunits expressed in brain areas (e.g. hypothalamus) also are involved in energy balance maintenance, such as alpha 7 nicotinic cholinergic receptor. In this sense, a funcional impairment this subunit can be related development to obesity, diabetes mellitus type II and other metabolic diseases.
- Intervention
- Inclusion criteria: Acute or chronic manipulation of alpha7 nicotinic acetylcholine receptors subunit through intracerebroventricular, subcutaneous, intraperitoneal or oral administration of antagonists, agonists, miRNA, shRNA or siRNAs of those receptors. Genetically modified animals (GMA) that present deletion, knockdown or overexpression of those subunits. Exclusion criteria: Concomitant manipulation of another non-alpha7 nicotinic acetylcholine receptor either through pharmacological administration or genetic modification in the same animal.
- Comparator Control
- Inclusion criteria: Animals not submitted to acute or chronic manipulation of alpha7 nicotinic acetylcholine receptors subunits, either by having vehicle administration or by receiving antagonists, agonists, miRNA, shRNA or siRNAs of other non-nicotinic acetylcholine receptors. Wild-type animals or GMA that present any deletion, knockdown or overexpression to other receptors (e.g. non-alpha7 nicotinic acetylcholine receptors). Exclusion criteria: None
- Main Outcome
- Outcome Measure
- Inclusion criteria: Caloric expenditure (measures as body temperature, indirect or direct calorimetry, thermographic camera), food intake (measure as eating time, food intake, caloric intake and feed efficiency ratio), skeletal muscle metabolism metabolism (measure as GLUT4 levels, activity and levels of enzymes involved in lipid or glucose metabolism), liver metabolism (measure as activity and levels of enzymes and other molecules involved in glucose, glycogen and lipid metabolism), white adipose tissue (measure as activity and levels of enzymes and other molecules involved in lipolysis and lipogenesis), brown adipose tissue (measure as activity and levels of enzymes and other molecules involved in thermogenesis). Body composition (body weight, body weight gain, Lee’s index, body mass index, adipose tissues weight, DEXA analysis, muscular fiber type and carcass composition), biochemical profile (levels of glucose, cholesterol, triglycerides, insulin, leptin, cortisol, adiponectin in serum or plasma) and hypothalamic activity (neurons immunoreactivity, expression of peptides related to energy balance (e.g, NPY, AgRP, POMC and aMSH) Exclusion criteria: None
- Additional Outcome
- Study Method
- Keyword
- Animals; Homeostasis; Receptors, Nicotinic; alpha7 Nicotinic Acetylcholine Receptor
- Contact
- Wenicios Chaves [email protected]
- Organisational Affiliation
- State University of Campinas https://www.unicamp.br/unicamp/
- Funding Source
- The São Paulo Research Foundation (FAPESP) Grant number(s) 2020/06661-2, 2019/07615-7 and 2013/07607-8
- Other Selection Criteria
- Data from review papers will not be included in this work, however their references might be checked.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-29
- Registration Date
- 2021-04-23
- Anticipated Start Date
- 2021-03-25
- Anticipated Completion Date
- 2021-07-25
- Title Cn
- α7烟碱型乙酰胆碱受体亚基在外周组织能量稳态调节中的作用：系统评价
- Title En
- Role of alpha7 nicotinic acetylcholine receptor subunit on modulation of energy homeostasis in peripheral tissues: a systematic review
- Bilingual Status
- complete