Meta AnalysisID 898
醋酸应用于烧伤创面疗效的系统评价
CRD42021243089
This review seeks to address the effectiveness of acetic acid application to burn wounds. Effectiveness will be defined in broad terms for example: ● (1) wound infection rates, bacterial load, and microbial resistance p
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 898
- Evidence Id
- 9456
- Core Evidence Id
- 9456
- Source Meta Analysis Id
- 872
- Herb2 Meta Analysis Id
- HBMA000872
- Crd Id
- CRD42021243089
- Title
- A systematic review of the efficacy of acetic acid application to burn wounds
- Review Question
- This review seeks to address the effectiveness of acetic acid application to burn wounds. Effectiveness will be defined in broad terms for example: ● (1) wound infection rates, bacterial load, and microbial resistance patterns, ● (2) time to wound healing, ● (3) scar quality, ● (4) patient tolerability (pain, pruritus) ● (5) concentration half-life, frequency of use
- Study Type Included
- Studies must report one of the outcomes of interest. Case reports or series n<10 will be excluded. All other studies will be included in the search.
- Condition Being Studied
- Despite many advancements in burn wound care and infection control, infection is the leading cause of mortality. In patients that survive, infections account for 9% -17% of all burn injury related complications and can lead to delayed healing and poor scarring. There are a variety of topical treatments in burn care but there is no consensus best practice and there is little already known about the effectiveness of acetic acid on burn wounds.
- Participant
- Studies involving human populations of patients treated for burn injury, total body surface area > 1%, due to flame, scald or other means. Both retrospective and prospective studies will be included.
- Animal
- Human Disease Modelled
- Intervention
- The intervention is acetic acid application at any concentration (0.5-5%) for any length of treatment time. Studies considering acetic acid in combination with other antimicrobial treatments will also be considered as part of the review.
- Comparator Control
- Control treatment is any other form of wound treatment, either standard non-antimicrobial treatments or antimicrobial treatments involving different therapeutic agents.
- Main Outcome
- Outcomes of interest, as available, are: (1) wound infection rates, bacterial load, and microbial resistance patterns, (2) time to wound healing, (3) scar quality, (4) patient tolerability (pain, pruritus) (5) concentration half-life, frequency of use Measures of effect All measures of effect are considered. Including relative risks, odds ratios, risk difference, and/or 'number needed to treat and raw data and numbers.
- Outcome Measure
- Additional Outcome
- None Measures of effect Not applicable
- Study Method
- Intervention, Meta-analysis, Narrative synthesis, Network meta-analysis, Systematic review
- Keyword
- Acetic Acid; Humans; Wound Infection
- Contact
- Liam Cato [email protected]
- Organisational Affiliation
- Scar Free Foundation Birmingham Centre for Burns Research, University Hospitals Birmingham Foundation Trust, Queen Elizabeth Hospital Birmingham; NIHR Surgical Reconstruction and Microbiology Research Centre, University Hospitals Birmingham Foundation Trust https://www.research.uhb.nhs.uk/birmingham-burns-research-centre/;
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- No existing systematic reviews on this topic.
- Published Protocol
- Review Type
- Language
- English
- Country
- England, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2021-03-16
- Registration Date
- 2021-03-18
- Anticipated Start Date
- 2021-04-01
- Anticipated Completion Date
- 2021-07-01
- Title Cn
- 醋酸应用于烧伤创面疗效的系统评价
- Title En
- A systematic review of the efficacy of acetic acid application to burn wounds
- Bilingual Status
- complete