Meta AnalysisID 892
在宫颈筛查或评估的女性中，应用醋酸或卢戈氏碘液时智能手机宫颈图像采集检测CIN 2+的诊断准确性
CRD42020204024
To evaluate the accuracy of smart phone image capture of the cervix after the application of acetic acid and / or Lugol’s iodine in the diagnosis of CIN 2 + in women undergoing cervical screening and assessment Populatio
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 892
- Evidence Id
- 9450
- Core Evidence Id
- 9450
- Source Meta Analysis Id
- 867
- Herb2 Meta Analysis Id
- HBMA000867
- Crd Id
- CRD42020204024
- Title
- The diagnostic test accuracy of smart phone image capture of the cervix at the time of acetic acid or Lugol's iodine application in the detection of CIN 2+ in women undergoing cervical screening or assessment
- Review Question
- To evaluate the accuracy of smart phone image capture of the cervix after the application of acetic acid and / or Lugol’s iodine in the diagnosis of CIN 2 + in women undergoing cervical screening and assessment Population: Women with positive cervical screening (either HPV, cytology, VIA) who undergo cervical assessment, image capture, and diagnosis Setting: Community health clinics, hospital-based settings, all income level countries Index test: Smart phone cervical imaging after application of acetic acid and / or Lugol's iodine Reference standard: Cytology, histopathology Target condition: CIN 2 +
- Study Type Included
- The ideal study design for diagnostic test performance is cross-sectional where the test is performed on consecutively assessed patients is cross-classified with disease status and a reference test. Although less ideal, randomised control trials that use previously independently assessed tests will also be considered.
- Condition Being Studied
- CIN 2 + (cervical intraepithelial neoplasia grade 2 or 3, adenocarcinoma in situ or invasive malignancy) lesion
- Participant
- Women with positive cervical screening (either HPV, cytology, VIA)
- Animal
- Human Disease Modelled
- Intervention
- Smart phone cervical imaging after application of acetic acid and / or Lugol's iodine
- Comparator Control
- While the ideal reference standard for the diagnosis of CIN 2+ is histology, we will also consider colposcopy as in many low and middle income countries the treatment of cervical disease is based on visual inspection alone and is done with cryotherapy, without confirmatory histopathology.
- Main Outcome
- Primary objective: to evaluate the accuracy of smart phone image capture of the cervix after the application of acetic acid and / or Lugol's iodine in the diagnosis of CIN 2 + in women with positive cervical screening The outcome is defined as a positive screening test for CIN 2+ if the images captured by the smart phone are considered to be positive (demonstrative of CIN 2+) and comparison to the reference standards will be made. Measures of effect We will plot the correlation coefficient (or sensitivity) of smart phone image capture of the cervix along with the 95% confidence intervals (CIs) using forest plots.
- Outcome Measure
- Additional Outcome
- - Secondary objectives 1. To compare the accuracy of smart phone images with traditional colposcopy 2. To describe the potential barriers to implementation of the technology, including quality of the images 3. To assess the patient acceptability of smart phone use in cervical screening Measures of effect 1. We will plot the correlation coefficient (or sensitivity) of smart phone image capture of the cervix along with the 95% confidence intervals (CIs) using forest plots. 2. The measure of this objective will be descriptive only 3. The measure of this objective will be descriptive only
- Study Method
- Diagnostic, Meta-analysis, Systematic review
- Keyword
- Acetates; Cervix Uteri; Diagnostic Tests, Routine; Early Detection of Cancer; Female; Humans; Iodine; Smartphone; Uterine Cervical Neoplasms
- Contact
- Emma Allanson [email protected]
- Organisational Affiliation
- The University of Texas MD Anderson Cancer Center https://www.mdanderson.org/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Australia, United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2020-08-13
- Registration Date
- 2020-09-12
- Anticipated Start Date
- 2020-07-10
- Anticipated Completion Date
- 2020-09-30
- Title Cn
- 在宫颈筛查或评估的女性中，应用醋酸或卢戈氏碘液时智能手机宫颈图像采集检测CIN 2+的诊断准确性
- Title En
- The diagnostic test accuracy of smart phone image capture of the cervix at the time of acetic acid or Lugol's iodine application in the detection of CIN 2+ in women undergoing cervical screening or assessment
- Bilingual Status
- complete