Meta AnalysisID 87
巴西药用植物治疗骨关节炎有效性与安全性的系统评价与Meta分析：研究方案
CRD42015019793
What is the efficacy and safety of herbal drugs sold in Brazil for the treatment of osteoarthritis?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 87
- Evidence Id
- 8645
- Core Evidence Id
- 8645
- Source Meta Analysis Id
- 79
- Herb2 Meta Analysis Id
- HBMA000079
- Crd Id
- CRD42015019793
- Title
- Systematic review and meta-analyses of effectiveness and safety of Brazilian medicinal plants in the treatment of osteoarthritis: study protocol
- Review Question
- What is the efficacy and safety of herbal drugs sold in Brazil for the treatment of osteoarthritis?
- Study Type Included
- Randomized controlled trials including an arm in which patients received one of the 13 herbal medicines listed below compared to an arm in which patients receive an inert (placebo) or an active non-herbal medicine control.
- Condition Being Studied
- Osteoarthritis affects 1% of world population and is the most common cause of musculoskeletal impairment in the elderly, becoming a major challenge to health systems. It was found that some medicinal plants are effective for this condition, however, there were no systematic reviews investigating the effects of medicinal plants used in Brazil for the treatment of pain due to osteoarthritis.
- Participant
- Patients: Studies must include adults (>18 years old) with osteoarthritis diagnosis according to the criteria of American College of Rheumatology (ACR) (ALTMAN, 1991) or the equivalent criterion of European League Against Rheumatism (EULAR): lequesne index (ZHANG, 2010).
- Animal
- Human Disease Modelled
- Intervention
- Studies must include an arm in which patients are taking one of the 13 herbal medicines used by the Brazilian population from any of the following plant preparations (whole, powder, extract, standardised mixture) with one of the select plants: Harpagophytum procumbens DC. ex Meisn., Uncaria tomentosa (Willd.) DC., Boswellia serrata Roxb. ex Colebr., Bowdichia virgilioides Kunth., Curcuma longa L. (or Curcuma domestica Valeton), Chenopodium ambrosioides L., Cordia curassavica (Jacq.) Roem. & Schult. (or Cordia verbenacea DC.), Salix alba L., Salix daphnoides Vill, Salix purpurea L., Persea gratissima Gaertn.f. (or Persea americana Mill.), Uncaria guianesis (Aubl.) J.F. Gmel and Zingiber officinale Roscoe. Studies that associated the use of the plant with homeopathy, aromatherapy, or preparation of synthetic origin; and studies that investigated the simultaneous use of more than one of the eligible plants will be excluded.
- Comparator Control
- Studies in which patients are compared to a control group (patients receive placebo or a non-herbal medicine controls, for example, a nonsteroidal anti-inflammatory drug - NSAID).
- Main Outcome
- Our outcomes will be consistent with those proposed by the Cochrane Musculoskeletal Group systematic intervention reviews for osteoarthritis (ALTMAN, 1996; PHAM, 2004). Primary outcomes: •
- Outcome Measure
- Additional Outcome
- Study Method
- Systematic review
- Keyword
- Brazil; Humans; Osteoarthritis; Osteoarthritis, Knee; Plants, Medicinal; Safety
- Contact
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Review Stage
- First Submission Date
- Registration Date
- Anticipated Start Date
- Anticipated Completion Date
- Title Cn
- 巴西药用植物治疗骨关节炎有效性与安全性的系统评价与Meta分析：研究方案
- Title En
- Systematic review and meta-analyses of effectiveness and safety of Brazilian medicinal plants in the treatment of osteoarthritis: study protocol
- Bilingual Status
- complete