Meta AnalysisID 830
西咪替丁、甲吡唑或calmangafodipir在接受静脉N-乙酰半胱氨酸治疗的醋氨酚（对乙酰氨基酚）中毒患者中的应用
CRD42020156946
Patient: Human with acute acetaminophen poisoning Intervention: addition of cimetidine or fomepizole or calmangafodipir to standard treatment with intravenous or oral N-acetylcysteine. Comparison: intravenous or oral N-a
Relationship Network
Interactive first-hop connections across herbs, ingredients, formulas, targets, diseases, symptoms, syndromes, evidence, and monographs.
Click a node to open it in a new tab
Ingredient: 1Meta-analysis: 1Links: 1
Arranging relationship network...
Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 830
- Evidence Id
- 9388
- Core Evidence Id
- 9388
- Source Meta Analysis Id
- 802
- Herb2 Meta Analysis Id
- HBMA000802
- Crd Id
- CRD42020156946
- Title
- Cimetidine, fomepizole, or calmangafodipir in patients with acetaminophen (paracetamol) poisoning treated with IV N-acetylcysteine.
- Review Question
- Patient: Human with acute acetaminophen poisoning Intervention: addition of cimetidine or fomepizole or calmangafodipir to standard treatment with intravenous or oral N-acetylcysteine. Comparison: intravenous or oral N-acetylcysteine alone. Outcomes (when reported): frequency of survival, severity of hepatic injury (measured by frequency of AST or ALT > 1000 IU/L, magnitude of highest transaminase concentration, frequency of metabolic acidosis, magnitude of lowest pH).
- Study Type Included
- No restrictions.
- Condition Being Studied
- Severe acetaminophen (paracetamol) poisoning
- Participant
- Human with acute acetaminophen poisoning
- Animal
- Human Disease Modelled
- Intervention
- Treatment with a currently available inhibitor of CYP 2E1 (cimetidine or fomepizole) or superoxide dismutase (SOD) mimetic (calmangafodipir) in addition to standard treatment (intravenous or oral N-acetylcysteine) in cases of severe acetaminophen poisoning. Severe acetaminophen poisoning includes patients with high acetaminophen concentrations (i.e. above the 200 mcg/mL line of the Rumack-Matthew nomogram) or metabolic acidosis with any acetaminophen concentration.
- Comparator Control
- Acute acetaminophen poisoning treated with intravenous or oral N-acetylcysteine alone
- Main Outcome
- Survival, hepatotoxicity (measured by serum AST and/or ALT concentrations), severity of poisoning effects (meeting King's College Criteria, lactic acidosis). Measures of effect N/A
- Outcome Measure
- Additional Outcome
- None Measures of effect N/A
- Study Method
- Systematic review
- Keyword
- Acetaminophen; Acetylcysteine; Cimetidine; Edetic Acid; Fomepizole; Humans; N, N'-bis(pyridoxal-5-phosphate)ethylenediamine-N, N'-diacetic acid; Pyridoxal Phosphate
- Contact
- Michael Mullins [email protected]
- Organisational Affiliation
- Washington University School of Medicine
- Funding Source
- Other Selection Criteria
- Final Publication
- Michael E. Mullins, Lauren H. Yeager & William E. Freeman (2020) Metabolic and mitochondrial treatments for severe paracetamol poisoning: a systematic review, Clinical Toxicology, DOI: 10.1080/15563650.2020.1798979 https://doi.org/10.1080/15563650.2020.1798979
- Same Topic Review
- None to our knowledge. No similar review has PROSPERO registration.
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Completed published
- First Submission Date
- 2019-11-07
- Registration Date
- 2020-04-28
- Anticipated Start Date
- 2019-08-01
- Anticipated Completion Date
- 2020-03-31
- Title Cn
- 西咪替丁、甲吡唑或calmangafodipir在接受静脉N-乙酰半胱氨酸治疗的醋氨酚（对乙酰氨基酚）中毒患者中的应用
- Title En
- Cimetidine, fomepizole, or calmangafodipir in patients with acetaminophen (paracetamol) poisoning treated with IV N-acetylcysteine.
- Bilingual Status
- complete