Meta AnalysisID 828
妇科泌尿手术中使用葡萄糖酸氯己定对比聚维酮碘阴道消毒后手术部位感染：一项系统评价与Meta分析
CRD42022378101
Is vaginal preparation with Chlorhexidine gluconate more effective in decreasing rates of surgical site infection than Iodine in vaginal preparation in women undergoing urogynecologic procedures?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 828
- Evidence Id
- 9386
- Core Evidence Id
- 9386
- Source Meta Analysis Id
- 800
- Herb2 Meta Analysis Id
- HBMA000800
- Crd Id
- CRD42022378101
- Title
- Surgical site infections after urogynecologic procedures using chlorhexidine gluconate versus povidone iodine vaginal antisepsis: a systematic review and meta-analysis
- Review Question
- Is vaginal preparation with Chlorhexidine gluconate more effective in decreasing rates of surgical site infection than Iodine in vaginal preparation in women undergoing urogynecologic procedures?
- Study Type Included
- Randomized trials and observational studies.
- Condition Being Studied
- Postoperative infections are a common complication of urogynecologic procedures. The most common are surgical site infections and urinary tract infection. The effects of these complications include an increase in healthcare costs, increased morbidity, and a higher mortality rate for patients. The vaginal microbiota is known to increase the risk of postoperative infections, hence best practices recommend preoperative antiseptic vaginal cleansing. Chlorhexidine gluconate is the preferred antiseptic for abdominal surgical procedures since it demonstrated fewer postoperative infections when compared to povidone-iodine. In addition, some studies suggest that chlorhexidine's prolonged antiseptic effect is associated with a decreased incidence of infection. The American College of Obstetricians and Gynecologists recommends both chlorhexidine or iodine for preoperative vaginal cleansing. However, iodine is currently the only Food and Drug Administration approved antiseptic agent for vaginal surgeries. Therefore, this study aims to compare the efficacy of chlorhexidine and iodine vaginal cleansing in preventing postoperative infection of urogynecologic surgeries.
- Participant
- We will include randomized controlled trials (RCTs) and observational studies comparing Chlorhexidine with Iodine in women undergoing urogynecologic procedures, reporting the clinical outcomes of interest. We will exclude studies with obstetrical patients and overlapping patient populations.
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Vaginal cleansing with Chlorhexidine gluconate, any concentration.
- Comparator Control
- Control: Vaginal cleansing with Povidone Iodine Solution, any concentration.
- Main Outcome
- We will extract data for a pooled analysis on the following outcomes: (1) surgical site infections; (2) UTI; (3) postoperative complications. Measures of effect Odds ratio.
- Outcome Measure
- Additional Outcome
- We will collect the following additional outcomes if data is available: (1) Infection not surgically related; (2) Positive colonies; and (3) vaginal culture positive specimens. Measures of effect Odds ratio.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Antisepsis; Female; Humans; Iodine; Povidone-Iodine; Surgical Wound Infection; chlorhexidine gluconate
- Contact
- Yasmin Dias [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil, United States of America, Wales
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-11-22
- Registration Date
- 2022-11-23
- Anticipated Start Date
- 2022-11-15
- Anticipated Completion Date
- 2022-12-22
- Title Cn
- 妇科泌尿手术中使用葡萄糖酸氯己定对比聚维酮碘阴道消毒后手术部位感染：一项系统评价与Meta分析
- Title En
- Surgical site infections after urogynecologic procedures using chlorhexidine gluconate versus povidone iodine vaginal antisepsis: a systematic review and meta-analysis
- Bilingual Status
- complete