Meta AnalysisID 824
使用碘伏对比葡萄糖酸氯己定阴道准备后子宫切除术后手术部位感染：一项系统评价
CRD42022349521
Does vaginal preparation with chlorhexidine gluconate decrease rates of surgical site infection compared wtih iodopho preparations at the time of hysterectomy?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 824
- Evidence Id
- 9382
- Core Evidence Id
- 9382
- Source Meta Analysis Id
- 796
- Herb2 Meta Analysis Id
- HBMA000796
- Crd Id
- CRD42022349521
- Title
- Surgical Site Infections After Hysterectomy Using Iodophor vs Chlorhexidine Gluconate Vaginal Preparation: A Systematic Review
- Review Question
- Does vaginal preparation with chlorhexidine gluconate decrease rates of surgical site infection compared wtih iodopho preparations at the time of hysterectomy?
- Study Type Included
- • Randomized control trials (N≥30/group) • Prospective or retrospective non-randomized comparative studies (consecutively enrolled) (N≥30/group) • Single arm studies, prospective or retrospective (for desquamation only) (N >100) • Include conference abstracts • Include systematic reviews (for their reference lists) • No restriction on geographic location/country of study • No language restriction (if translatable) • Studies published after 1985
- Condition Being Studied
- More than 30% of women over the age of 50 have undergone a hysterectomy. The rate of surgical site infection after hysterectomy is 1-4%. Healthcare bundles have been developed to minimize this risk including perioperative preparation of the vagina with povidone iodone solution and scrub. Chlorhexidine gluconate, however, has been found to be superior in preventing surgical site infections compared to iodophor scrubs in bowel surgery and at the time of vascular catheter insertions. However, there is little evidence comparing vaginal antisepsis with chlorhexidine gluconate vs povidone iodine in preventing surgical site infections.
- Participant
- Population: Women undergoing hysterectomy Include: - Women undergoing hysterectomy for both benign and oncologic reasons This includes vaginal, abdominal, and laparoscopic approaches - Include hysterectomy at the time of other gynecologic procedures (urogynecologic including mesh, oncologic, etc.) - All women in each analyzed group MUST have undergone hysterectomy for study to be included Exclude: - Women with gynecologic infection: pelvic inflammatory disease (PID), tuboovarian abscess studies that do not separate hysterectomy data from other gynecologic surgeries - Women undergoing REI-related procedures such as oocyte retrieval - Obstetrical patients - Studies with hysterectomies and concomitant non-gynecologic surgeries (ex: colorectal, bowel resection) animal or in vitro studies
- Animal
- Human Disease Modelled
- Intervention
- Vaginal cleansing with: - Chlorhexidine gluconate, any concentration - Chloraprep
- Comparator Control
- Povidone cleanser (betadine) - PVP-I - PI - Iodophor cleanser No comparator (for desquamation outcome only)
- Main Outcome
- Primary: Surgical site infections (superficial, deep, organ space) as defined by the CDC
- Outcome Measure
- Additional Outcome
- Infection not surgically related -UTI -Fever -Temp greater than 38C -Sepsis -Positive wound cultures -Vaginal culture positive specimens -Colony forming units -Positive cultures Adverse Events Events related to skin antisepsis -Desquamation Pruritis, erythema Hypersensitivity Chemical skin burns OR fires
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Chlorhexidine; Female; Humans; Hysterectomy; Iodophors; Surgical Wound Infection; chlorhexidine gluconate
- Contact
- Sarah Rozycki [email protected]
- Organisational Affiliation
- Houston Methodist Hospital https://www.houstonmethodist.org/womens-services/pelvic-health/urogynecology/
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- United States of America
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-08-05
- Registration Date
- 2022-08-16
- Anticipated Start Date
- 2022-06-14
- Anticipated Completion Date
- 2023-02-28
- Title Cn
- 使用碘伏对比葡萄糖酸氯己定阴道准备后子宫切除术后手术部位感染：一项系统评价
- Title En
- Surgical Site Infections After Hysterectomy Using Iodophor vs Chlorhexidine Gluconate Vaginal Preparation: A Systematic Review
- Bilingual Status
- complete