Meta AnalysisID 822
不同浓度氯己定的抗牙菌斑效果：一项系统评价与网状Meta分析
CRD42022327083
We aimed to collect RCTs comparing different concentrations of chlorhexidine or between chlorhexidine and placebo in healthy people, and conduct a NMA to evaluate the comparative effects of different concentrations of ch
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 822
- Evidence Id
- 9380
- Core Evidence Id
- 9380
- Source Meta Analysis Id
- 794
- Herb2 Meta Analysis Id
- HBMA000794
- Crd Id
- CRD42022327083
- Title
- Effect of different concentrations of chlorhexidine on anti-plaque: A systematic review and network meta-analysis
- Review Question
- We aimed to collect RCTs comparing different concentrations of chlorhexidine or between chlorhexidine and placebo in healthy people, and conduct a NMA to evaluate the comparative effects of different concentrations of chlorhexidine on anti-plaque, in order to provide reference for nurses to choose the appropriate concentration of chlorhexidine in clinical oral care practice in the future.
- Study Type Included
- Randomized controlled trials (RCTs), study using a pre-post intervention design, or pilot studies with control groups
- Condition Being Studied
- Hospital-acquired pneumonia (HAP) is defined as pneumonia acquired after at least 2 days of hospitalization and when no underlying disease is suspected prior to admission. It can be caused by a variety of microorganisms, such as bacteria, respiratory viruses and fungi, and is an important component of hospital-acquired infection. The annual incidence of HAP in adults worldwide is 5 to 10 per 1000 hospitalized patients, and the global mortality rate caused by HAP is about 20% to 30%. Lower respiratory tract infections, including HAP, affected 489 million people world. HAP mostly occurs in immunocompromised patients, postoperative and elderly patients, and oropharyngeal colonization is the main mechanism leading to HAP.
- Participant
- Healthy adults without systemic disease.
- Animal
- Human Disease Modelled
- Intervention
- Clinically commonly used chlorhexidine mouthwashes, gels or sprays at specified concentrations
- Comparator Control
- Clinically commonly used chlorhexidine mouthwashes, gels, sprays at specified concentrations or placebo (including distilled water or normal saline)
- Main Outcome
- Plaque index and the incidence of adverse effects
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Network meta-analysis, Systematic review
- Keyword
- Anti-Infective Agents, Local; Chlorhexidine; Humans; Mouthwashes; Network Meta-Analysis
- Contact
- Shiqi Liang [email protected]
- Organisational Affiliation
- Sichuan University, Chengdu, China
- Funding Source
- This work was supported by Science and Technology Department of Sichuan Province. Grant number(s) <span style=font-size: 14px>State the funder, grant or award number and the date of award</span> grant number 2021YFS0156, 2021.04 -2023.03
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-04-20
- Registration Date
- 2022-05-10
- Anticipated Start Date
- 2021-12-12
- Anticipated Completion Date
- 2022-05-31
- Title Cn
- 不同浓度氯己定的抗牙菌斑效果：一项系统评价与网状Meta分析
- Title En
- Effect of different concentrations of chlorhexidine on anti-plaque: A systematic review and network meta-analysis
- Bilingual Status
- complete