Meta AnalysisID 821
氯己定在种植体周围炎/种植体周围黏膜炎非手术治疗中的效果：一项更新后的系统评价与Meta分析
CRD42022315308
Population: Patients with peri-implantitis/peri-implant mucositis Intervention: Use of local application of chlorhexidine in any form Comparison: None or placebo Outcomes: Probing depth, bleeding on probing
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 821
- Evidence Id
- 9379
- Core Evidence Id
- 9379
- Source Meta Analysis Id
- 793
- Herb2 Meta Analysis Id
- HBMA000793
- Crd Id
- CRD42022315308
- Title
- Effect of chlorhexidine in non-surgical treatment of peri-implantitis/peri-implant mucositis : an updated systematic review and meta-analysis
- Review Question
- Population: Patients with peri-implantitis/peri-implant mucositis Intervention: Use of local application of chlorhexidine in any form Comparison: None or placebo Outcomes: Probing depth, bleeding on probing
- Study Type Included
- Randomised controlled trials or Controlled clinical trials shall be included. Retrospective studies shall be excluded.
- Condition Being Studied
- Biological complications affecting the supporting tissues at dental implants include peri-implant mucositis and peri-implantitis. Peri-implant mucositis is defined as inflammation of the peri- implant soft tissues without loss of supporting bone and has been reported to occur in up to 80% of patients with implants. A clinical diagnosis of peri-implant mucositis is made when there is bleeding following probing of the peri-implant sulcus, in the absence of radiographic bone loss. In contrast, when there is bone loss around an implant in addition to bleeding on probing (BOP), the diagnosis is peri-implantitis. The peri-implant soft tissues are similar in composition to their gingival counterparts around teeth and respond in a similar way to biofilm formation, with an inflammatory cell infiltrate. It is assumed that peri-implant mucositis is the pre- cursor for peri-implantitis, as gingivitis is the precursor for periodontitis. Several in vitro investigations have demonstrated that chlorhexidine (CHX) is adsorbed to the oxide layer of titanium surfaces. It has also been shown that the absorption kinetics is directly related to implants’ surface roughness and was also positively correlated with the concentration of the CHX solution. Desorption occurs within 24 hours and inhibits bacterial growth.
- Participant
- Population: Patients with peri-implantitis/peri-implant mucositis
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Use of local application of chlorhexidine in any form
- Comparator Control
- Comparison: None or placebo
- Main Outcome
- Probing depth and Bleeding on probing
- Outcome Measure
- Additional Outcome
- Clinical attachment levels, Any other gingival or periodontal indices reported by the included studies (Same outcome should be reported by at least three studies for inclusion in the review).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Chlorhexidine; Humans; Mucositis; Peri-Implantitis; Risk Factors; Stomatitis
- Contact
- Mingfu Ye [email protected]
- Organisational Affiliation
- Stomatological Hospital of Xiamen Medical College.
- Funding Source
- Nil
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2022-03-07
- Registration Date
- 2022-04-07
- Anticipated Start Date
- 2022-03-09
- Anticipated Completion Date
- 2022-04-09
- Title Cn
- 氯己定在种植体周围炎/种植体周围黏膜炎非手术治疗中的效果：一项更新后的系统评价与Meta分析
- Title En
- Effect of chlorhexidine in non-surgical treatment of peri-implantitis/peri-implant mucositis : an updated systematic review and meta-analysis
- Bilingual Status
- complete