Meta AnalysisID 8028
中老年人群补充维生素D与骨折发生率和预后的相关性：系统评价和Meta分析
CRD42023449899
To investigate whether calcium, vitamin D, or calcium and vitamin D supplementation is associated with a reduced incidence of fractures in middle-aged and older adults
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 8028
- Evidence Id
- 16586
- Core Evidence Id
- 16586
- Source Meta Analysis Id
- 8028
- Herb2 Meta Analysis Id
- HBMA008028
- Crd Id
- CRD42023449899
- Title
- Association Between Vitamin D Supplementation and Fracture Incidence/prognosis in middle age and Older Adults A Systematic Review and Meta-analysis
- Review Question
- To investigate whether calcium, vitamin D, or calcium and vitamin D supplementation is associated with a reduced incidence of fractures in middle-aged and older adults
- Study Type Included
- We will include randomised trials to assess the beneficial effects of the treatments
- Condition Being Studied
- Employer loose-related hip fractures are generally considered the most severe type of osteoporotic fracture. Studies have shown that more than one in five patients dies within 1 year of a hip fracture. Survivors may need more social and care. The increased social and economic burden associated with osteoporosis-related fractures globally makes their prevention a major public health goal. Practice guidelines recommend vitamin D supplementation in older adults to prevent fractures in patients with osteoporosis. However, the meta-analyses published to date have not reached consistent conclusions on the relationship between calcium, vitamin D supplementation and fracture risk/prognosis in middle-aged and older adults.
- Participant
- Contains: adult patients with osteoporosis (diagnosis using any accepted diagnostic criteria).
- Animal
- Human Disease Modelled
- Intervention
- Inclusion Criteria: (1) RC comparing vitamin D or a combination supplement of calcium and placebo or no treatment; (2) trials recruiting adults over the age of 50; (3) Tests that provide fracture data. Exclusion Criteria: (1) no randomised trials with placebo or treatment groups; (2) trials of participants with secondary osteoporosis; (3) trials combining vitamin D or supplemental supplements with other treatments (e.g., hormone， anti-osteoporotics);
- Comparator Control
- Placebo. A group of osteoporosis patients who were not exposed to vitamin D. no treatment
- Main Outcome
- we extracted those fracture data from forest plots of the metaanalysis and reviewed original articles to confirm whether the trials met our inclusion criteria
- Outcome Measure
- Additional Outcome
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Aged; Calcium; Calcium, Dietary; Dietary Supplements; Fractures, Bone; Humans; Incidence; Middle Aged; Prognosis; Vitamin D; Vitamins
- Contact
- Shen Huarui [email protected]
- Organisational Affiliation
- Affiliated Traditional Chinese Medical Hospital of Southwest Medical University, Sichuan Province, Luzhou, 646000, P.R. China; http://www.swmctcm.com/index.html
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed not published
- First Submission Date
- 2023-08-05
- Registration Date
- 2023-08-15
- Anticipated Start Date
- 2023-08-06
- Anticipated Completion Date
- 2023-09-28
- Title Cn
- 中老年人群补充维生素D与骨折发生率和预后的相关性：系统评价和Meta分析
- Title En
- Association Between Vitamin D Supplementation and Fracture Incidence/prognosis in middle age and Older Adults A Systematic Review and Meta-analysis
- Bilingual Status
- complete