Meta AnalysisID 8027
孕期补充维生素D的时机与剂量反应：随机对照试验的系统评价和贝叶斯网状Meta分析
CRD42023432314
Our review will be based on the following PICOT question: "Based on randomized controlled trials (T), for pregnant women (P), how different doses of vitamin D with varying frequencies of administration (I) perform when c
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 8027
- Evidence Id
- 16585
- Core Evidence Id
- 16585
- Source Meta Analysis Id
- 8027
- Herb2 Meta Analysis Id
- HBMA008027
- Crd Id
- CRD42023432314
- Title
- Timing and Dose-response of Vitamin D Supplementation during Pregnancy: A Systematic Review and Bayesian Network Meta-analysis of Randomized Controlled Trials
- Review Question
- Our review will be based on the following PICOT question: "Based on randomized controlled trials (T), for pregnant women (P), how different doses of vitamin D with varying frequencies of administration (I) perform when compared against each other or to placebo (C) considering the outcomes preeclampsia, gestational diabetes, pregnancy loss, preterm birth, low birth weight, hypercalcemia and hypercalciuria(O)?"
- Study Type Included
- We will include only randomized controlled trials (RCTs) that report any of the outcomes of interest (preeclampsia, gestational diabetes, pregnancy loss, preterm birth, low birth weight, hypercalcemia and hypercalciuria). Our analyses will exclude: (1) non-randomized studies; (2) trials without outcomes of interest; (3) overlapping populations, defined as studies with overlapping institutions and recruitment periods; and (4) conference abstracts.
- Condition Being Studied
- Sufficient levels of vitamin D are essential for the absorption of calcium, maintaining healthy bones, and supporting the immune system. These factors directly affect both the mother and the developing fetus. Previous meta-analyses have indicated that supplementing with vitamin D during pregnancy might decrease the likelihood of complications like preeclampsia and gestational diabetes. However, there is no consensus on the appropriate timing and dosage of vitamin D supplementation. Furthermore, the disparity in benefits between patients with and without a vitamin D deficiency is still unclear. Thus, this study aims to fill this knowledge gap by synthesizing the existing evidence.
- Participant
- Pregnant women. Exclusion criteria: (1) participants who started intervention before pregnancy; and (2) studies that included patients less than 18 years old.
- Animal
- Human Disease Modelled
- Intervention
- We will incorporate studies that compare the following interventions against each other or against a placebo: low dose (< 1000 IU), moderate dose (1000 – 2000 IU), or high dose (> 2000 IU) of vitamin D supplementation. Additionally, we will compare interventions involving different frequencies of administration (daily, weekly, or monthly).
- Comparator Control
- Placebo.
- Main Outcome
- Preeclampsia, gestational diabetes, pregnancy loss and preterm birth. Measures of effect Relative risks (RR).
- Outcome Measure
- Additional Outcome
- Low birth weight, maternal hypercalcemia and hypercalciuria. Measures of effect Relative risks (RR).
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Bayes Theorem; Cholestanes; Diabetes, Gestational; Dietary Supplements; Female; Humans; Hypercalcemia; Hypercalciuria; Infant, Newborn; Pre-Eclampsia; Pregnancy; Pregnant Women; Premature Birth; Randomized Controlled Trials as Topic; Vitamin D; Vitamins
- Contact
- Henrique Provinciatto [email protected]
- Organisational Affiliation
- Barao de Maua University Center
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-03
- Registration Date
- 2023-06-14
- Anticipated Start Date
- 2023-06-04
- Anticipated Completion Date
- 2023-08-31
- Title Cn
- 孕期补充维生素D的时机与剂量反应：随机对照试验的系统评价和贝叶斯网状Meta分析
- Title En
- Timing and Dose-response of Vitamin D Supplementation during Pregnancy: A Systematic Review and Bayesian Network Meta-analysis of Randomized Controlled Trials
- Bilingual Status
- complete