Meta AnalysisID 8026

补充维生素D对炎症性肠病是否有益？一项伞状评价

CRD42023468978

Participants (P): Adults and children diagnosed with inflammatory bowel disease (IBD). Intervention (I): Vitamin D supplementation, including different dosages, forms (e.g., vitamin D2 or D3), and duration of supplementa

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Meta Analysis Id: 8026
Evidence Id: 16584
Core Evidence Id: 16584
Source Meta Analysis Id: 8026
Herb2 Meta Analysis Id: HBMA008026
Crd Id: CRD42023468978
Title: Does Vitamin D Supplementation Benefit Inflammatory Bowel Disease? An Umbrella Review of the Evidence
Review Question: Participants (P): Adults and children diagnosed with inflammatory bowel disease (IBD). Intervention (I): Vitamin D supplementation, including different dosages, forms (e.g., vitamin D2 or D3), and duration of supplementation. Comparison (C): Comparison groups may include individuals with IBD who did not receive vitamin D supplementation or those who received a placebo or standard care. Outcomes (O): Clinical outcomes such as disease activity, symptom relief, quality of life, remission rates, and adverse effects. Secondary outcomes may include changes in inflammatory markers, bone health, and other relevant outcomes. Study Design (S): Systematic reviews and meta-analyses of various types of interventional studies will be included in the study.
Study Type Included: Systematic Reviews and Meta-Analyses: Studies must be systematic reviews or meta-analyses that have synthesized evidence from various types of interventional studies. Interventional Studies: The systematic reviews and meta-analyses included should encompass a range of interventional study designs, such as randomized controlled trials (RCTs), non-randomized controlled trials, before-and-after studies, quasi-experimental studies, and other experimental study designs. Relevance to Research Question: Included systematic reviews and meta-analyses must be directly relevant to the research question and objectives of this review.
Condition Being Studied: The systematic review investigates the role of vitamin D supplementation in the management and treatment of inflammatory bowel disease (IBD). Inflammatory bowel disease encompasses chronic inflammatory conditions of the gastrointestinal tract, primarily including Crohn's disease and ulcerative colitis. IBD is characterized by symptoms such as abdominal pain, diarrhea, fatigue, and weight loss, and it can significantly impact the quality of life of affected individuals. The review aims to synthesize and evaluate the existing evidence on the effectiveness and safety of vitamin D supplementation as an adjunctive therapy in the management of IBD, considering various clinical outcomes and patient populations, including both adults and children.
Participant: Diagnosis of Inflammatory Bowel Disease (IBD): Individuals of all ages with a confirmed diagnosis of IBD, including Crohn's disease and ulcerative colitis.
Animal
Human Disease Modelled
Intervention: Intervention with Vitamin D: Studies involving the administration of vitamin D supplementation, regardless of the dosage, formulation (e.g., vitamin D2 or D3), or duration of supplementation.
Comparator Control: 1. Non-Intervention or Placebo Control: Studies that compare vitamin D supplementation with a non-intervention group or a placebo control group will be included. 2. Standard of Care or Conventional Treatment Control: Studies comparing vitamin D supplementation in addition to standard of care or conventional treatment with a group receiving standard of care or conventional treatment alone will be included. 3. Alternative Interventions: Studies comparing vitamin D supplementation with alternative interventions for managing IBD will be included if available.
Main Outcome: 1. Disease Activity and Clinical Remission: • Definition: Disease activity will be assessed based on recognized clinical activity indices such as the Crohn's Disease Activity Index (CDAI) for Crohn's disease and the Mayo Clinic Score for ulcerative colitis. Clinical remission will be defined as a reduction in disease activity to a specified threshold or score indicating remission. • Measurement: Disease activity and clinical remission will be measured through clinical assessments, including physical examinations and patient-reported symptom scores. • Timing of Measurement: Outcomes will be assessed at various time points during the follow-up period, with specific time frames recorded when available in the included studies. 2. Improvement in Nutrition: • Definition: Improvement in nutrition refers to changes in dietary intake, nutritional status, and nutritional markers as a result of vitamin D supplementation. • Measurement: Improvement in nutrition will be evaluated based on dietary assessments, nutritional status indicators (e.g., serum levels of specific nutrients), and changes in dietary patterns. • Timing of Measurement: Nutritional outcomes will be assessed at specified intervals during the follow-up period, with recorded time frames from the included studies.
Outcome Measure
Additional Outcome: 1. Quality of Life: • Definition: Quality of life refers to the overall well-being and health-related quality of life of individuals with inflammatory bowel disease. • Measurement: Quality of life will be assessed using standardized health-related quality of life questionnaires such as the Inflammatory Bowel Disease Questionnaire (IBDQ) or other validated tools. • Timing of Measurement: Quality of life will be evaluated at specified intervals during the follow-up period, with recorded time frames from the included studies. 2. Adverse Events: • Definition: Adverse events include any undesirable, unintended, or harmful effects of vitamin D supplementation. • Measurement: Adverse events will be assessed through reports of side effects, complications, or any harmful outcomes related to vitamin D supplementation. • Timing of Measurement: Adverse events will be recorded throughout the study duration and reported as they occur. Measures of effect
Study Method: Narrative synthesis, Review of reviews, Systematic review
Keyword: MeSH headings have not been applied to this record
Contact: Qingyong Zheng [email protected]
Organisational Affiliation: Evidence-Based Medicine Center, School of Basic Medical Sciences, Lanzhou University
Funding Source: None.
Other Selection Criteria
Final Publication
Same Topic Review
Published Protocol
Review Type
Language: English
Country: China
Review Stage: Review Ongoing
First Submission Date: 2023-10-03
Registration Date: 2023-10-14
Anticipated Start Date: 2023-09-29
Anticipated Completion Date: 2023-12-31
Title Cn: 补充维生素D对炎症性肠病是否有益？一项伞状评价
Title En: Does Vitamin D Supplementation Benefit Inflammatory Bowel Disease? An Umbrella Review of the Evidence
Bilingual Status: complete