Meta AnalysisID 8023
评估维生素D在治疗创伤性脑损伤中的神经保护作用
CRD42023462014
1. What is the neuroprotective effect of Vitamin D in treatment of Traumatic Brain Injury? 2. What is the role of Vitamin D in attenuating neuronal damage and preserving cognitive function after TBI? 3. What is the optim
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Record Fields
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- Meta Analysis Id
- 8023
- Evidence Id
- 16581
- Core Evidence Id
- 16581
- Source Meta Analysis Id
- 8023
- Herb2 Meta Analysis Id
- HBMA008023
- Crd Id
- CRD42023462014
- Title
- Assessing the neuroprotective effect of vitamin D in the treatment of traumatic brain injury
- Review Question
- 1. What is the neuroprotective effect of Vitamin D in treatment of Traumatic Brain Injury? 2. What is the role of Vitamin D in attenuating neuronal damage and preserving cognitive function after TBI? 3. What is the optimal dosage of Vitamin D supplementation needed for favourable neuroprotection in patients with TBI?
- Study Type Included
- Inclusion criteria: All relevant literature will be searched including randomized control trials, non-randomized controlled clinical trials, Case studies, case reports, all observational studies: case-control and cohort studies describing the use of Vitamin D in the treatment of Traumatic Brain Injury and only articles reported in English will be included. Relevant references from the selected studies will also be considered. Exclusion criteria: All literature based on opinion studies and letters will be excluded. Case series, abstract-only articles, letters to the editor, conference proceedings, review articles, articles with missing data in other languages, studies including animals will not be included also studies describing the use of Vitamin D in non-Traumatic Brain Injury patients and other disease conditions will also be excluded.
- Condition Being Studied
- Traumatic insult to the brain leads to primary or secondary injuries. Primary injuries result from the primary insult to the brain parenchyma While secondary injuries result from immune response and free radical damage to the neural cells following the primary insult. Vitamin D is a fat soluble vitamin with multiple biological effects, its antioxidant and anti-immune effects have been hypothesized to attenuate the process of secondary brain injury and this has been proven in animal studies.
- Participant
- Inclusion: studies including humans with Traumatic Brain Injury will be included. Exclusion: studies including animals will not be included.
- Animal
- Human Disease Modelled
- Intervention
- Inclusion: studies describing the use of Vitamin D in Traumatic Brain Injury patients will be included. Exclusion: studies describing the use of Vitamin D in non-Traumatic Brain Injury patients and other disease conditions will be excluded.
- Comparator Control
- Not applicable
- Main Outcome
- Primary outcome: Mortality rate, survival rate, and incidence of complications
- Outcome Measure
- Additional Outcome
- Secondary outcome: Pain scores, mean length of stay
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Brain; Brain Injuries, Traumatic; Cholestanes; Dietary Supplements; Humans; Neuroprotection; Neuroprotective Agents; Vitamin D; Vitamins
- Contact
- Mubarak Jolayemi Mustapha [email protected]
- Organisational Affiliation
- Evidence-Based Scientific Consortium (EBASC) www.ebasc.com
- Funding Source
- No funding
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Bangladesh, Congo, Democratic Republic, France, India, Kenya, Lebanon, Libya, Niger, Nigeria, Saudi Arabia, Tanzania, Uganda
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-09-09
- Registration Date
- 2023-09-11
- Anticipated Start Date
- 2023-09-10
- Anticipated Completion Date
- 2024-10-10
- Title Cn
- 评估维生素D在治疗创伤性脑损伤中的神经保护作用
- Title En
- Assessing the neuroprotective effect of vitamin D in the treatment of traumatic brain injury
- Bilingual Status
- complete