Meta AnalysisID 8022
维生素D作为神经病理性疼痛的新型疗法：系统评价
CRD42023433300
What is the evidence of efficacy of vitamin D as therapy for relieving neuropathic pain intensity ?
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Record Fields
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- Meta Analysis Id
- 8022
- Evidence Id
- 16580
- Core Evidence Id
- 16580
- Source Meta Analysis Id
- 8022
- Herb2 Meta Analysis Id
- HBMA008022
- Crd Id
- CRD42023433300
- Title
- Vitamin D a novel therapy for neuropathic pain : A Systematic Review
- Review Question
- What is the evidence of efficacy of vitamin D as therapy for relieving neuropathic pain intensity ?
- Study Type Included
- Inclusion criteria : randomized controlled trials (RCTs) with focused in efficacy of vitamin D at 2 weeks or more after intervention in patients with neuropathic pain Exclusion criteria : case report, case series , expert opinion, cross- sectional studies , abstract- only papers, duplicated studies, studies with data not reliable ectracted or overlapping data, articles without available full text.
- Condition Being Studied
- Neuropathic pain is defined as pain caused by a lesion or disease of the somatosensory nervous system. It is estimated that the incidence of neuropathic pain ranges from 2 – 40% of the adult population. Pain that arises continuously will have a negative impact on sufferers, causing depression, sleep disturbances, mood disorders, physical and social functioning disorders. Neuropathic pain is associated with poor emotional and physical functioning. The current management of neuropathic pain is still a challenge because the existing pharmacotherapy (anti-inflammatory and anti-neuropathy pain medication) has not provided satisfactory results and the emergence of various side effects that are uncomfortable for the sufferer.
- Participant
- Inclusion : This studied selected for: 1.adults ( > 18 years) participant, without dicrimination of (race, etnicity, gender and geography) 2. Participant who diagnosed by physician with neuropathic pain from symtomps, sign, or validated neurophatic pain scoring systems (e.g. Dn4, NPS), 3. pain assessment using VAS and NRS . the intensity should be moderate or severe in intensity (using NRS the score > 4 or using VAS the score 30/100, 4.included studies that assesed patient suffering neurophatic pain caused by spinal cord injury pain, post stroke pain , multiple sclerosis associated pain, cervical radiculopty, sciatica, diabetic neuropathy, non diabetic painful polyneuropathy, neuropathy cancer related pain, HIV/AIDS associated neuropaty pain , post hepertic neuralgia, post traumatic or post-surgical neuropathic pain including plexus avulsion and complex regional pain syndrome type 2, Osthoartritis with sign of neuropaty pain, trigeminal neuralgia. Studies in outpatient, and adult population . Exclusion : 1.Adolescent ( <18 years) 2.Child population 3.Women pregnancy population 4.Case with no sysmtops of neuropthic pain
- Animal
- Human Disease Modelled
- Intervention
- Inclusion : Participant who received vitamin D ( no restriction on dosage, drug formulation, duration of therapy and route of administration ) Exclusion : any other treatment regimen
- Comparator Control
- Participant who received placebo or standard treatment for neuropathic pain
- Main Outcome
- Improvement on neuropathic pain in terms of pain score, by many assement of neuropahic pain (ex. VAS Score, NPS, DN4 Score and etc) at 2 weeks or more after the intervention, increasing functional outcome by specific functional questionnaire (ex. NeuroQol, Boston funtional status scale score and etc) , or any other subjective measure of improvement of pain Measures of effect the specific main outcome from this research was Standardized mean difference (SMD) using continuous variable [(mean)±(standard deviation) and number of sample (n)] and Risk ratio . so that it can determine the degree of significance of the therapy from p-value and 95% confidence interval
- Outcome Measure
- Additional Outcome
- none Measures of effect none
- Study Method
- Intervention, Systematic review
- Keyword
- Cholestanes; Humans; Neuralgia; Vitamin D; Vitamins
- Contact
- Hajar Mar'atussholikah Supriyanto [email protected]
- Organisational Affiliation
- Airlangga University
- Funding Source
- No funding sources Grant number(s) State the funder, grant or award number and the date of award no grant sources
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Indonesia
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-21
- Registration Date
- 2023-09-01
- Anticipated Start Date
- 2023-08-01
- Anticipated Completion Date
- 2023-09-30
- Title Cn
- 维生素D作为神经病理性疼痛的新型疗法：系统评价
- Title En
- Vitamin D a novel therapy for neuropathic pain : A Systematic Review
- Bilingual Status
- complete