Meta AnalysisID 8002
个体化与常规卵巢刺激促性腺激素起始剂量选择的疗效与安全性：随机对照试验的贝叶斯网状Meta分析
CRD42023358439
Whether individualized ovarian stimulation protocol can achieve comparable assitant reproductive outcomes and reduce the incidence of OHSS compared with conventional ovarian stimulation protocol
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 8002
- Evidence Id
- 16560
- Core Evidence Id
- 16560
- Source Meta Analysis Id
- 8001
- Herb2 Meta Analysis Id
- HBMA008001
- Crd Id
- CRD42023358439
- Title
- Efficacy and Safety of Individualized versus Conventional Ovarian Stimulation for Gonadotropin Starting Dose Selection: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
- Review Question
- Whether individualized ovarian stimulation protocol can achieve comparable assitant reproductive outcomes and reduce the incidence of OHSS compared with conventional ovarian stimulation protocol
- Study Type Included
- Only RCT study compared individualized with conventional ovulation stimulation was included.
- Condition Being Studied
- infertility couples treat with assisted reproductive technology
- Participant
- Inclusion criteria: 1、RCT study 2、Individualized versus Conventional ovulation stimulation 3、Outcome Report at least one of the following data: ovulation stimulation outcome(obtained oocytes, poor response rate, duration of stimulation, total dose of gonadotropin use, OHSS rate), treatment outcome (clinical pregnancy rate, live birth rate). Exclusion criteria: Donor eggs and embryos, abstracts, reviews, case reports, non-English articles, repeated data/articles.
- Animal
- Human Disease Modelled
- Intervention
- Individualized ovulation stimulation based on following one or more markers: Anti-Müllerian Hormone (AMH), Antral Follicle Count (AFC), age, Body Mass Index (BMI), Follicle-Stimulating Hormone (FSH), height, weight, basal Estradiol (E2), doppler score, ovarian volume and smoking
- Comparator Control
- Conventional ovulation stimulation based on clinical experience
- Main Outcome
- OHSS rate and live birth rate
- Outcome Measure
- Additional Outcome
- duration of stimulation, total gonadotropin dose, number of oocytes retrieved, proportion of patients with appropriate response (5-15 retrieved oocytes), proportion of patients with hypo-response (<5 retrieved oocytes), proportion of patients with hyper-response (>15 or >20 retrieved oocytes), proportion of patients with severe OHSS (sOHSS, defined as clinical ascites(occasionally hydrothorax), oliguria, haemoconcentration with haematocrit >45% or hypoproteinaemia, and ovarian size usually >12 cm) , clinical pregnancy rate Measures of effect relative risk (RR) with 95% CIs for dichotomous endpoints and weighted mean difference (WMD) with 95% CIs for continuous endpoints
- Study Method
- Network meta-analysis, Systematic review
- Keyword
- Humans
- Contact
- Yangqin Peng [email protected]
- Organisational Affiliation
- Reproductive and Genetic hospital of CITIC-Xiangya http://www.zxxyyy.cn/
- Funding Source
- Hunan Provincial Grant for Innovative Province Construction Grant number(s) State the funder, grant or award number and the date of award 2019SK4012
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-07
- Registration Date
- 2023-03-18
- Anticipated Start Date
- 2022-07-01
- Anticipated Completion Date
- 2023-04-30
- Title Cn
- 个体化与常规卵巢刺激促性腺激素起始剂量选择的疗效与安全性：随机对照试验的贝叶斯网状Meta分析
- Title En
- Efficacy and Safety of Individualized versus Conventional Ovarian Stimulation for Gonadotropin Starting Dose Selection: A Bayesian Network Meta-Analysis of Randomized Controlled Trials
- Bilingual Status
- complete