Meta AnalysisID 7977
维生素K2促进骨质疏松症中的骨损伤修复：一项系统文献综述
CRD42023465053
Does the Vitamin K2 promote the repair of bone injury in osteoporotic animal models? Context and rationale Osteoporosis and osteoporosis -related bone injury are increasingly common in women over 55 years of age and men
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Record Fields
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- Meta Analysis Id
- 7977
- Evidence Id
- 16535
- Core Evidence Id
- 16535
- Source Meta Analysis Id
- 7977
- Herb2 Meta Analysis Id
- HBMA007977
- Crd Id
- CRD42023465053
- Title
- Vitamin K2 Promotes Bone injury Repair in Osteoporosis: A Systematic Literature Review
- Review Question
- Does the Vitamin K2 promote the repair of bone injury in osteoporotic animal models? Context and rationale Osteoporosis and osteoporosis -related bone injury are increasingly common in women over 55 years of age and men over 65 years of age, especially in postmenopausal older women who have hip fracture due to OP in particular can be devastating, because it is expensive to treat and carries a high risk of death. Previous studies have shown that vitamin K plays an important role in the preventive treatment of osteoporotic bone injury, because vitamin K is required during the carboxylation of osteocalcin, and it also seems to promote the conversion of osteoblasts to osteoblasts, and limit the formation of osteoclasts. However, the answer to the question of whether vitamin K2 can improve the repair of bone damage and maintain bone density in various parts of the body in patients who already have osteoporotic bone injury has been unclear. The aim of this review study was to discuss and summarize whether the vitamin K2 can improve the repair of bone damage in preclinical studies to propose an optimal strategy for vitamin K to promote the healing of osteoporotic bone injury.
- Study Type Included
- Inclusion criteria: Controlled studies with a separate control group, randomized controlled trial. Exclusion criteria: Case studies, cross-over studies, studies without a separate control group.
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All animals model with bone injury and osteoporosis. Exclusion criteria: Ex vivo studies, in vitro studies.
- Human Disease Modelled
- Osteoporosis;Bone injury(defect/trauma).
- Intervention
- Inclusion criteria: Treated with Vitamin K2. All timings, frequencies and dosages of treatment are eligible for inclusion. Exclusion criteria: Treated without Vitamin K2.
- Comparator Control
- Inclusion criteria: In vivo animal model with bone injury, and treated without Vitamin K2. Exclusion criteria: All other control conditions.
- Main Outcome
- Outcome Measure
- Inclusion criteria: the amount, area, volume and quality of bone repair, measured by histology analysis, radiograhic analysis and biomechanical analysis. Exclusion criteria: No relevant outcomes reported.
- Additional Outcome
- Study Method
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Yu Tian [email protected]
- Organisational Affiliation
- The Second Hospital of Jilin University https://en.jdey.jlu.edu.cn/
- Funding Source
- 1. the Department of Finance of Jilin Province, P.R. China 2. the Education Department of Jilin Province, P.R. China Grant number(s) 1.Grant Number 3D5197435429 and3D5204944429 2.Grant Number JJKH20211157KJ
- Other Selection Criteria
- Inclusion criteria: all languages. Exclusion criteria: reviews, conference proceedings, expert opinion articles and book chapters.
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Animal model review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-10-07
- Registration Date
- 2023-11-08
- Anticipated Start Date
- 2023-10-15
- Anticipated Completion Date
- 2024-02-29
- Title Cn
- 维生素K2促进骨质疏松症中的骨损伤修复：一项系统文献综述
- Title En
- Vitamin K2 Promotes Bone injury Repair in Osteoporosis: A Systematic Literature Review
- Bilingual Status
- complete