Meta AnalysisID 7904
芝麻素对肥胖相关疾病动物模型的影响：一项系统评价和Meta分析
CRD42023438502
Does sesamin have an effect on animal models of obesity-associated diseases? Context and rationale Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disea
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Record Fields
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- Meta Analysis Id
- 7904
- Evidence Id
- 16462
- Core Evidence Id
- 16462
- Source Meta Analysis Id
- 7899
- Herb2 Meta Analysis Id
- HBMA007899
- Crd Id
- CRD42023438502
- Title
- Effects of Sesamin in animal models of obesity-associated diseases: Asystematic review and meta-analysis
- Review Question
- Does sesamin have an effect on animal models of obesity-associated diseases? Context and rationale Obesity is a major risk factor for several diseases, including metabolic syndrome (MetS), non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes (T2D). The use of natural products, such as Sesamin, the main lignin constituent of sesame, plays a pivotal role in regulating physical state. pluvialis, has gained particular interest to reduce oxidative stress and inflammation, and to improve redox status, often associated with obesity. A systematic review and meta-analysis was performed to comprehensively examine the effects of sesamin in animal models of diet induced obesity-associated diseases in order to inform the design of future human clinical studies for sesamin use as supplement or nutraceutical.
- Study Type Included
- Inclusion criteria: controlled studies with a separate control group Exclusion criteria: case studies, cross-over studies, studies without a separate control group
- Condition Being Studied
- Participant
- Animal
- Inclusion criteria: All rodents with obesity diseases such as metabolic syndrome, type 2 diabetes and nonalcoholic fatty liver, all sexes and all ages Exclusion criteria: (i)animals that are not rodents;(ii)T1D;（iii）In vitro research
- Human Disease Modelled
- Non-human animal models of obesity-associated diseases
- Intervention
- Inclusion criteria: sesamin (>90% purity) via daily oral to produce a therapeutic effect on diabetes mellitus 2, metabolic syndrome and Non alcoholic fatty liver disease. Exclusion criteria: (i)sesamin were studied in combination with other drugs;(ii)sesamin are less than 90% pure
- Comparator Control
- Inclusion criteria: Animal models of obesity-associated diseases induced treated with vehicle / placebo, or standard treatment and healthy animal control. Exclusion criteria: Animal models treated with any other drug, experiments without control group.
- Main Outcome
- Outcome Measure
- Inclusion criteria: We will evaluate the efficacy of sesamin on Blood glucose levels, insulin levels TC TG AST ALT SOD Iiver weight SBP CAT GPX4 AKT GSK-3 TNF-α IL-6 MDA and body weight in diabetic rodents Exclusion criteria: Measurements of parameters other than those cited above.
- Additional Outcome
- Study Method
- Keyword
- Animals; Biological Products; Diabetes Mellitus, Type 2; Dietary Supplements; Humans; Inflammation; Lignin; Metabolic Syndrome; Non-alcoholic Fatty Liver Disease; Obesity; Oxidation-Reduction; Oxidative Stress; Risk Factors; Sesamum; sesamin
- Contact
- ZUO JINSHI [email protected]
- Organisational Affiliation
- 河北医科大学 https://www.hebmu.edu.cn
- Funding Source
- National Natural Science Foundation of China Grant number(s) No. 81874264
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Experimental animal exposure review
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-27
- Registration Date
- 2023-07-12
- Anticipated Start Date
- 2023-05-30
- Anticipated Completion Date
- 2023-08-07
- Title Cn
- 芝麻素对肥胖相关疾病动物模型的影响：一项系统评价和Meta分析
- Title En
- Effects of Sesamin in animal models of obesity-associated diseases: Asystematic review and meta-analysis
- Bilingual Status
- complete