Meta AnalysisID 7901
补硒对血液透析患者的影响：Meta分析
CRD42023493510
Meta-analysis was effect of selenium supplementation on dialysis patients
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7901
- Evidence Id
- 16459
- Core Evidence Id
- 16459
- Source Meta Analysis Id
- 7897
- Herb2 Meta Analysis Id
- HBMA007897
- Crd Id
- CRD42023493510
- Title
- Effect of selenium supplementation on hemodialysis patients: a meta-analysis
- Review Question
- Meta-analysis was effect of selenium supplementation on dialysis patients
- Study Type Included
- We will include randomized controls to evaluate the effect
- Condition Being Studied
- Hemodialysis patients (HD) have high levels of oxidative stress and inflammation, which can subsequently lead to malnutrition. Some studies have shown that hemodialysis itself increases the production of free radicals. Among various nutritional elements, selenium is associated with patients with CKD. There is substantial evidence that selenium levels are reduced in patients with chronic kidney disease, especially those on hemodialysis. Selenium (Se) is an important trace mineral in the human body that plays an important role in the free radical scavenging system, helping the body defend against oxidative stress. Since selenium deficiency can cause oxidative stress and inflammatory responses, selenium may be an effective supplement to reduce the severity of malnutrition in HD patients by reducing oxidative stress and inflammation.
- Participant
- Inclusion: adult patients on maintenance hemodialysis Exclusion: Patients aged under 18 years old, patients with acute kidney injury, patients undergoing other renal replacement therapy.
- Animal
- Human Disease Modelled
- Intervention
- We will incorporate hemodialysis that has been started for more than 6 months. Exclusion criteria were viral hepatitis or other infectious diseases, steroid and non-steroidal anti-inflammatory drug use, and pregnant women
- Comparator Control
- Placebo
- Main Outcome
- We will look at BMI, triglyceride, total cholesterol, low density lipoprotein, high density lipoprotein, cholesterol, C-reactive Changes in protein, ferritin, Hx-c reactive protein, hemoglobin, and selenium
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- MeSH headings have not been applied to this record
- Contact
- Qiu Cheng [email protected]
- Organisational Affiliation
- West China Hospital of Sichuan University
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-12-14
- Registration Date
- 2023-12-25
- Anticipated Start Date
- 2023-11-08
- Anticipated Completion Date
- 2024-04-30
- Title Cn
- 补硒对血液透析患者的影响：Meta分析
- Title En
- Effect of selenium supplementation on hemodialysis patients: a meta-analysis
- Bilingual Status
- complete