Meta AnalysisID 7897
补硒对TPOAb阳性孕妇的影响：随机对照试验的Meta分析
CRD42023452914
Does selenium supplementation in pregnant women with autoimmune thyreoiditis reduces TPOAb titer?
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7897
- Evidence Id
- 16455
- Core Evidence Id
- 16455
- Source Meta Analysis Id
- 7894
- Herb2 Meta Analysis Id
- HBMA007894
- Crd Id
- CRD42023452914
- Title
- Selenium supplementation on TPOAb pregnant women: a meta-analysis of randomized controlled trials
- Review Question
- Does selenium supplementation in pregnant women with autoimmune thyreoiditis reduces TPOAb titer?
- Study Type Included
- Only randomized controlled trials will be included.
- Condition Being Studied
- Se supplementation is expected to improve inflammatory status in patients with autoimmune thyroiditis, especially in those with high activity, and has been demonstrated as effective in reducing the thyroid peroxidase antibodies titer. Se status seems to affect thyroid function in pregnancy, which prompts the potential role of Se supplementation in such patients. Some clinical trials have investigated the effectiveness of Se supplementation in pregnant women with thyroiditis, and their results suggest the safety and effectiveness of this element in reducing autoantibody levels and preventing postpartum thyroiditis development, although limited.
- Participant
- We will include randomized controlled trials (RCTs) comparing selenium supplementation with placebo in Pregnant women with positive antithyroid antibodies. We will exclude studies with overlapping patient populations, as well as studies without a control group.
- Animal
- Human Disease Modelled
- Intervention
- Selenium supplementation
- Comparator Control
- Placebo or nothing
- Main Outcome
- Main outcome is decrease of thyroid peroxidase autoantibodies (TPOAb). Measures of effect Hazards radio or odds ratio.
- Outcome Measure
- Additional Outcome
- Alteration on TSH (thyroid stimulating hormone), FT4 (levothyroxin) levels. Measures of effect Hazards ratio or odds ratio.
- Study Method
- Intervention, Meta-analysis, Systematic review
- Keyword
- Dietary Supplements; Female; Humans; Iodide Peroxidase; Pregnancy; Pregnant Women; Randomized Controlled Trials as Topic; Selenium
- Contact
- Jessica Fernanda Cassemiro [email protected]
- Organisational Affiliation
- Federal University of Bahia https://www.ufba.br/entidades/instituto-de-ciencias-da-saude
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Brazil
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-08-08
- Registration Date
- 2023-08-19
- Anticipated Start Date
- 2023-08-22
- Anticipated Completion Date
- 2023-11-20
- Title Cn
- 补硒对TPOAb阳性孕妇的影响：随机对照试验的Meta分析
- Title En
- Selenium supplementation on TPOAb pregnant women: a meta-analysis of randomized controlled trials
- Bilingual Status
- complete