Meta AnalysisID 7894
膳食硒摄入与非酒精性脂肪性肝病的关联：系统评价与Meta分析
CRD42023434801
Selenium is one of the necessary trace elements for human body, which plays an important role in the process of anti-oxidation and anti-inflammation. Therefore, it has been suggested that dietary supplements containing s
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7894
- Evidence Id
- 16452
- Core Evidence Id
- 16452
- Source Meta Analysis Id
- 7891
- Herb2 Meta Analysis Id
- HBMA007891
- Crd Id
- CRD42023434801
- Title
- Associations between dietary selenium intake and non-alcoholic fatty liver disease: a systematic review and meta-analysis
- Review Question
- Selenium is one of the necessary trace elements for human body, which plays an important role in the process of anti-oxidation and anti-inflammation. Therefore, it has been suggested that dietary supplements containing selenium should be used to improve hepatic steatosis. However, recent studies have found that dietary selenium intake is positively correlated with the prevalence of non-alcoholic fatty liver disease. As there are contradictions in epidemiological studies on the relationship between selenium and non-alcoholic fatty liver disease, we aim to study the above inconsistencies through systematic review and meta-analysis.
- Study Type Included
- The type of research design that meets the inclusion criteria should be observational because randomized controlled trials are unethical. However, all studies on inclusion should describe the relationship between selenium intake and non-alcoholic fatty liver disease. Studies are excluded according to several criteria: 1) repeated articles; 2) lack of baseline information; 3) review articles; 4) animal experiments; 5) have nothing to do with the content of this study.
- Condition Being Studied
- Nonalcoholic fatty liver disease (NAFLD) is characterized by fat accumulation in the liver, which can range from simple steatosis to more severe nonalcoholic steatohepatitis, and may eventually progress to liver cirrhosis, which is considered to be the main cause of chronic liver disease. Selenium is one of the necessary trace elements for human body, which plays an important role in the process of anti-oxidation and anti-inflammation. Therefore, dietary supplements containing selenium have been recommended for a long time to prevent cell damage caused by free radicals. However, recent studies have found that dietary selenium intake is positively correlated with the prevalence of non-alcoholic fatty liver disease. Because of the contradiction between selenium and non-alcoholic fatty liver disease, we aim to study the relationship between dietary selenium supplement and non-alcoholic fatty liver disease, so as to promote healthy diet.
- Participant
- Inclusion: 1. Dietary supplements contain selenium. 2. The end point of the study was non-alcoholic fatty liver disease. Exclusion: 1. The quality of literature is low. 2. Lack of baseline information. 3. The data is not appropriate.
- Animal
- Human Disease Modelled
- Intervention
- Dietary selenium intake level
- Comparator Control
- We evaluated dietary selenium intake, and participants with less than a certain amount of selenium intake will be included in the non-exposed control group.
- Main Outcome
- The main outcome is nonalcoholic fatty liver disease. The diagnosis of NAFLD is based on imaging or histological evidence of liver steatosis, history of heavy drinking, and exclusion of all other liver diseases. We will select articles based on the diagnosis. Measures of effect The main outcome is nonalcoholic fatty liver disease. The diagnosis of NAFLD is based on imaging or histological evidence of liver steatosis, history of heavy drinking, and exclusion of all other liver diseases. We will select articles based on the diagnosis.
- Outcome Measure
- Additional Outcome
- None Measures of effect None
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Human Body; Humans; Non-alcoholic Fatty Liver Disease; Prevalence; Selenium; Trace Elements
- Contact
- xu jiali [email protected]
- Organisational Affiliation
- Funding Source
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-13
- Registration Date
- 2023-06-24
- Anticipated Start Date
- 2023-06-12
- Anticipated Completion Date
- 2023-12-31
- Title Cn
- 膳食硒摄入与非酒精性脂肪性肝病的关联：系统评价与Meta分析
- Title En
- Associations between dietary selenium intake and non-alcoholic fatty liver disease: a systematic review and meta-analysis
- Bilingual Status
- complete