Meta AnalysisID 7893
心脏手术中补硒——减少术后并发症的途径？系统评价与Meta分析
CRD42023424920
Cardiac surgery is associated with declining levels of trace elements which predispose patients to worsening postoperative outcomes. The trace element, selenium, has specifically shown a protective effect against cardiov
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7893
- Evidence Id
- 16451
- Core Evidence Id
- 16451
- Source Meta Analysis Id
- 7889
- Herb2 Meta Analysis Id
- HBMA007889
- Crd Id
- CRD42023424920
- Title
- Selenium supplementation in cardiac surgery- A way to reduce post operative complications? A Systematic Review and Meta Analysis.
- Review Question
- Cardiac surgery is associated with declining levels of trace elements which predispose patients to worsening postoperative outcomes. The trace element, selenium, has specifically shown a protective effect against cardiovascular disease and supplementation with selenium helps reduce the mortality rate in patients with CVD. Metabolic therapy with selenium was noticed to also decrease the length of postoperative hospital stay (LOS), post operative sepsis, kidney injury and myocardial damage in patients undergoing CABG. Hence our study aims to assess whether intervention with selenium could help improve outcomes such as length of hospital stay, morality, organ failure, acute kidney injury and CK-MB, in patients undergoing cardiac surgery.
- Study Type Included
- Only RCTs were included in our review. Observational studies, commentaries, case letters and case reports were excluded from the study
- Condition Being Studied
- Postoperative outcomes of cardiac surgery have been evaluated in our meta analysis.
- Participant
- Our review includes adult patients (≥ 18 years) undergoing cardiac surgery (CABG, valvular surgery, aortic surgery, LVAD implantation, intra aortic balloon pump). Studies evaluating the effects of selenium on surgeries other than cardiac procedures were also eliminated from our paper.
- Animal
- Human Disease Modelled
- Intervention
- Intervention was with selenium pre or/and post operatively. Articles that administered other metabolites with selenium in the intervention group, such as Vitamin C, Zinc and Calcium were also excluded to exclusively see the effects of selenium on patients undergoing cardiac surgery
- Comparator Control
- Control group of placebo, normal saline or no selenium.
- Main Outcome
- Outcomes of interest included postoperative mortality, LOS in the hospital and ICU, AKI, troponin I and CK-MB.
- Outcome Measure
- Additional Outcome
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Acute Kidney Injury; Cardiovascular Diseases; Coronary Artery Bypass; Dietary Supplements; Humans; Kidney; Morals; Selenium; Sepsis; Trace Elements
- Contact
- Laiba Imran [email protected]
- Organisational Affiliation
- Dow Medical College
- Funding Source
- Our review did not receive any funds or sponsors.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- Pakistan
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-05-08
- Registration Date
- 2023-05-19
- Anticipated Start Date
- 2023-03-15
- Anticipated Completion Date
- 2023-06-10
- Title Cn
- 心脏手术中补硒——减少术后并发症的途径？系统评价与Meta分析
- Title En
- Selenium supplementation in cardiac surgery- A way to reduce post operative complications? A Systematic Review and Meta Analysis.
- Bilingual Status
- complete