Meta AnalysisID 7891
单独或联合应用硒或维生素E在ICU患者中的有效性与安全性：系统评价与Meta分析
CRD42023418840
The aim of this meta -analysis is to evaluate the efficacy and safety of selenium alone or vitamin E alone or in combination for ICU patients.
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7891
- Evidence Id
- 16449
- Core Evidence Id
- 16449
- Source Meta Analysis Id
- 7887
- Herb2 Meta Analysis Id
- HBMA007887
- Crd Id
- CRD42023418840
- Title
- Efficacy and safety of the administration of selenium or vitamin E alone or combined administration in ICU patients: a systematic review and meta-analysis
- Review Question
- The aim of this meta -analysis is to evaluate the efficacy and safety of selenium alone or vitamin E alone or in combination for ICU patients.
- Study Type Included
- Randomized controlled trials will be included.
- Condition Being Studied
- The patients admitted to the intensive care unit are all kinds of critical acute diseases, such as those who need to be monitored after major surgery, anesthesia accidents, severe combined trauma, acute circulatory failure, acute respiratory failure, resuscitation after cardiac and respiratory arrest, electric shock, resuscitation after drowning, various poisoning patients, various shock patients, sepsis, amniotic fluid embolism, severe pregnancy toxemia, etc.
- Participant
- Patients were eligible if they were expected to be on intensive care and high dependency units for ≥48 hours, were aged ≥16 years. Pregnant women were not eligible. Patients with estimated glomerular filtration rate <10 ml/min and not receiving renal replacement therapy were also excluded.
- Animal
- Human Disease Modelled
- Intervention
- Selenium, Vitamin E, or selenium in combination with vitamin E.
- Comparator Control
- The control group was patients who were not given the intervention or were given placebo.
- Main Outcome
- 1. SOFA score: It is a simple and objective score that allows for calculation of both the number and the severity of organ dysfunction in six different organs (respiratory, coagulatory, liver, cardiovascular, renal, and neurologic) ; 2. Length of stay in the ICU: It is a term introduced by the National Health Service (NHS) as the length of an inpatient hospitalization in ICU, calculated from the day when patients were admitted to the ICU to day of discharge based on the number of overnight stays; 3. Mortality. Measures of effect SOFA score and Length of stay in the ICU use RR. Mortality use SMD.
- Outcome Measure
- Additional Outcome
- Ventilator-free days: Ventilator-free days at 28 days is an outcome that depends on organ dysfunction. It is defned in a 28 day period in critically ill patients and measured by the number of free days from mechanical ventilation to evaluate the efcacy of interventions. Measures of effect Ventilator-free days use SMD.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Antioxidants; Humans; Intensive Care Units; Selenium; Vitamin E; Vitamins
- Contact
- Xin Lu [email protected]
- Organisational Affiliation
- Department of Critical Care Medicine, School of Anesthesiology, Naval Medical University
- Funding Source
- National Natural Science Foundation of China Grant number(s) State the funder, grant or award number and the date of award 81872880
- Other Selection Criteria
- Final Publication
- Lu X, Wang Z, Chen L, Wei X, Ma Y, Tu Y. Efficacy and safety of selenium or vitamin E administration alone or in combination in ICU patients: A systematic review and meta-analysis. Clinical Nutrition ESPEN. 2023;57:550-60 https://www.ScienceDirect.com/science/article/abs/pii/S2405457723011968
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Completed published
- First Submission Date
- 2023-04-20
- Registration Date
- 2023-04-30
- Anticipated Start Date
- 2023-03-27
- Anticipated Completion Date
- 2023-07-02
- Title Cn
- 单独或联合应用硒或维生素E在ICU患者中的有效性与安全性：系统评价与Meta分析
- Title En
- Efficacy and safety of the administration of selenium or vitamin E alone or combined administration in ICU patients: a systematic review and meta-analysis
- Bilingual Status
- complete