Meta AnalysisID 7881
口服毛果芸香碱或西维美林治疗干燥综合征患者干眼的疗效：一项系统评价和Meta分析
CRD42023405612
The purpose of this study is to explore whether oral pilocarpine or cevimiline can relieve symptoms of dry eye in patients with Sjogren's syndrome. Some studies have concluded that this treatment is effective for dry eye
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7881
- Evidence Id
- 16439
- Core Evidence Id
- 16439
- Source Meta Analysis Id
- 7877
- Herb2 Meta Analysis Id
- HBMA007877
- Crd Id
- CRD42023405612
- Title
- Efficacy of oral pilocarpine or cevimiline for the treatment of dry eye in patients with Sjogren's syndrome: A systematic review and meta-analysis
- Review Question
- The purpose of this study is to explore whether oral pilocarpine or cevimiline can relieve symptoms of dry eye in patients with Sjogren's syndrome. Some studies have concluded that this treatment is effective for dry eye, while some ones hold the opposite conclusion.
- Study Type Included
- There are no restrictions on the types of study designs. Case report, case series, prospective study, retrospective study, cohort study, etc.
- Condition Being Studied
- Sjögren's syndrome (SS) is a common autoimmune disease that primarily affects exocrine glands such as the lacrimal glands. Dry eye disease is one of the most prevalent complications of Sjögren's syndrome, affecting most patients. It significantly affects quality of life and treatment of Sjögren's syndrome is often difficult and unsatisfactory. Pilocarpine and carvimilin are muscarinic cholinergic agonists that have been used to treat Sjogren's syndrome. Whether oral pilocarpine can relieve dry eye symptoms in patients with Sjogren's syndrome remains to be investigated and opinions differ. So, this research tries to specifically explore this problem.
- Participant
- 1. All study types are included: case reports, case series, prospective studies, retrospective studies, cohort studies, and more. All studies are included, there is no limited time frame. 2. Inclusion criteria： ① patients with Sjögren's syndrome; ② treatment with conventional administration of oral pilocarpine and carvimilin, 3. Exclusion criteria: ①Irrelevant studies；②studies published in other languages than English；③lack of ocular surface parameters. 4. Observation: objective tests (Schirmer’s test, break-up time, Rose Bengal staining); subjective tests (symptoms’ questionnaire).
- Animal
- Human Disease Modelled
- Intervention
- Intervention: Patients diagnosed as Sjögren's syndrome were treated with oral pilocarpine and carvimilin.
- Comparator Control
- Placebo or Blank.
- Main Outcome
- The objective measurement of interest includes: • Schirmer’s Test • Phenol red thread test • Tear break-up time (TBUT) • Tear osmolarity • Tear meniscus height (TMH) The subjective measurement of interest includes: • Ocular surfaces disease index (OSDI) • Dry eye questionnaires (DEQ-5) • Dry Eye-Related Quality of Life Score (DEQS)
- Outcome Measure
- Additional Outcome
- Not applicable.
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Dry Eye Syndromes; Humans; Patients; Pilocarpine; Sjogren's Syndrome
- Contact
- nan zhou [email protected]
- Organisational Affiliation
- Nanjing University
- Funding Source
- None.
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-03-09
- Registration Date
- 2023-03-19
- Anticipated Start Date
- 2023-03-07
- Anticipated Completion Date
- 2023-05-08
- Title Cn
- 口服毛果芸香碱或西维美林治疗干燥综合征患者干眼的疗效：一项系统评价和Meta分析
- Title En
- Efficacy of oral pilocarpine or cevimiline for the treatment of dry eye in patients with Sjogren's syndrome: A systematic review and meta-analysis
- Bilingual Status
- complete