Meta AnalysisID 7877
邻苯二甲酸酯暴露与接受体外受精/卵胞浆内单精子注射女性生殖结局的关联：一项系统评价和Meta分析
CRD42023434583
(P) women who undergoing IVF/ICSI without restriction on regions and race, (E) phthalate exposure before IVF/ICSI , (C) participants from the same study, (O) assisted reproductive outcomes, and (S) cohort or cross-sectio
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Record Fields
Scalar fields from the final meta_analysis record.
- Meta Analysis Id
- 7877
- Evidence Id
- 16435
- Core Evidence Id
- 16435
- Source Meta Analysis Id
- 7873
- Herb2 Meta Analysis Id
- HBMA007873
- Crd Id
- CRD42023434583
- Title
- Association of phthalate exposure with reproductive outcomes among women undergoing IVF/ICSI: A systematic review and meta-analysis
- Review Question
- (P) women who undergoing IVF/ICSI without restriction on regions and race, (E) phthalate exposure before IVF/ICSI , (C) participants from the same study, (O) assisted reproductive outcomes, and (S) cohort or cross-sectional studies exploring associations between phthalate exposure and live birth and reporting estimated effects.
- Study Type Included
- Inclusion criteria: (1) studies that measured levels of phthalates or phthalate metabolites in body flfluid or tissue of target population; (2) studies that reported risk estimate and 95% confifident interval (CI) for the association between phthalate exposure and ART outcomes, or provided suffificient data for calculation of the crude risk estimate and variance. Effect measure should be either odds ratio (OR) or risk ratio (RR). Exclusion criteria: (1) they were published as an abstract, review, letter, case report, meta-analyses, commentary articles, conference posters without full text, animal or molecular experiment studies; (2) data of the articles were overlapped with other publications or there was no extractable data. Cohort or cross-sectional studies exploring the relationship between phthalate exposure and assisted reproductive outcomes will all likely be included in this study.
- Condition Being Studied
- Phthalates are considered to be an environmental hormone that is ubiquitous in living environments. Phthalates are mainly used in polyvinyl chloride materials to change polyvinyl chloride from a hard plastic to a flexible plastic, acting as a plasticizer. It is widely used in toys, food packaging materials, medical blood bags and hose, wallpaper, cleaning agents, lubricants, personal care products and other hundreds of goods. Packing butter, animal fat food with plastic bags, especially hot, can increase the intake of the phthalates and do harm to health. Epidemiologic studies indicated that phthalate exposure might be associated with IVF outcome. However, whether phthalate exposure contributes to adverse outcomes of assisted reproduction remains controversial.
- Participant
- Women exposed to phthalate levels prior to IVF/ICSI and women with assisted reproductive outcomes will be included in the study.
- Animal
- Human Disease Modelled
- Intervention
- The variables of interest are phthalate exposure in women who undergoing IVF/ICSI with assessment in urine samples.
- Comparator Control
- Studies used the first quartile or lowest phthalate concentration group as the reference and the last quartile or highest group estimate effect was the experimental group to investigate the association between phthalate exposure and assisted reproductive outcomes.
- Main Outcome
- The primary outcomes in this study were live birth rate (LBR)
- Outcome Measure
- Additional Outcome
- The secondary outcomes included fertilization rate (FR), implantation rate (IR), biochemical pregnancy rate (BPR) , clinical pregnancy rate (CPR) and miscarriage rate (MR)
- Study Method
- Meta-analysis, Systematic review
- Keyword
- Cross-Sectional Studies; Female; Humans; Live Birth; Phthalic Acids; Pregnancy; Sperm Injections, Intracytoplasmic; phthalic acid
- Contact
- Tian Xiangming [email protected]
- Organisational Affiliation
- Beijing Chao-Yang Hospital https://www.bjcyh.com.cn/
- Funding Source
- None Grant number(s) State the funder, grant or award number and the date of award None
- Other Selection Criteria
- Final Publication
- Same Topic Review
- Published Protocol
- Review Type
- Language
- English
- Country
- China
- Review Stage
- Review Ongoing
- First Submission Date
- 2023-06-30
- Registration Date
- 2023-07-11
- Anticipated Start Date
- 2023-06-30
- Anticipated Completion Date
- 2023-07-29
- Title Cn
- 邻苯二甲酸酯暴露与接受体外受精/卵胞浆内单精子注射女性生殖结局的关联：一项系统评价和Meta分析
- Title En
- Association of phthalate exposure with reproductive outcomes among women undergoing IVF/ICSI: A systematic review and meta-analysis
- Bilingual Status
- complete